Publikationen

Hier sind alle Publikationen der Klinischen Forschungsgruppe KFO342 zu finden. Die Publikationsliste wird in umgekehrt chronologischer Reihung geführt.

kfo342 research unit

Publikations­liste

10.04.24

Drost CC, Rovas A, Osiaevi I, Schughart K, Lukasz A, Linke WA, Pavenstädt H, Kümpers P. Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis. Angiogenesis. 2024 Apr 10. Epub ahead of print.

02.03.24

Schreiber A, Rodner F, Oberberg N, Anhlan D, Bletz S, Mellmann A, Planz O, Ludwig S. The host-targeted antiviral drug Zapnometinib exhibits a high barrier to the development of SARS-CoV-2 resistance. Antiviral Res. 2024 May; 225:105840.

29.01.24

Meersch M, Weiss R, Strauß C, Albert F, Booke H, Forni L, Pittet JF, Kellum JA, Rosner M, Mehta R, Bellomo R, Rosenberger P, Zarbock A; EPIS-AKI Investigators. Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial. Intensive Care Med. 2024 Feb;50(2):247-257

14.12.23

Soehnlein O, Döring Y. Beyond association: high neutrophil counts are a causal risk factor for atherosclerotic cardiovascular disease. Eur Heart J. 2023 Dec 14;44(47):4965-4967.

01.12.23

Liu C, Görlich D, Lowell CA, Italiano JE, Rossaint J, Bender M, Zarbock A, Margraf A. Thrombopoietin levels in sepsis and septic shock – a systematic review and meta-analysis. Clin Chem Lab Med. 2023 Dec 1. Online ahead of print.

30.11.23

Baluk P, Shirakura K, Vestweber D, McDonald DM. Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava. Cell Tissue Res. 2023 Nov 30. Online ahead of print.

29.11.23

Goretzko J, Pauels I, Heitzig N, Thomas K, Kardell M, Naß J, Krogsaeter EK, Schloer S, Spix B, Linard Matos AL, Leser C, Wegner T, Glorius F, Bracher F, Gerke V, Rossaint J, Grimm C, Rescher U. P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2. Cell Rep. 2023 Nov 29;42(12):113501.

30.10.23

Pruenster M, Immler R, Roth J, Kuchler T, Bromberger T, Napoli M, Nussbaumer K, Rohwedder I, Wackerbarth LM, Piantoni C, Hennis K, Fink D, Kallabis S, Schroll T, Masgrau-Alsina S, Budke A, Liu W, Vestweber D, Wahl-Schott C, Roth J, Meissner F, Moser M, Vogl T, Hornung V, Broz P, Sperandio M. E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation. Nat Immunol. 2023 Dec;24(12):2021-2031. Epub 2023 Oct 30.

31.08.23

Zarbock A, Forni LG, Ostermann M, Ronco C, Bagshaw SM, Mehta RL, Bellomo R, Kellum JA. Designing acute kidney injury clinical trials. Nat Rev Nephrol. 2023 Aug 31. Epub ahead of print.

13.08.23

Rovas A, Neumann JK, Drost CC, Vollenberg R, Thölking G, Fobker M, Witzenrath M, Kümpers P, Agamotto Study Group, Capnetz Study Group. Analysis of Urinary Glycosaminoglycans to Predict Outcome in COVID-19 and Community-Acquired Pneumonia-A Proof-of-Concept Study. J Clin Med. 2023 Aug 13;12(16):5269.

28.07.23

Zarbock A, Weiss R, Albert F, Rutledge K, Kellum JA, Bellomo R, Grigoryev E, Candela-Toha AM, Demir ZA, Legros V, Rosenberger P, Galán Menéndez P, Garcia Alvarez M, Peng K, Léger M, Khalel W, Orhan-Sungur M, Meersch M; The EPIS-AKI Investigators. Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study. Intensive Care Med. 2023 Jul 28. doi: 10.1007/s00134-023-07169-7. Epub ahead of print.

28.07.23

Groba SR, Soehnlein O. DRANquilizing neutrophil function in chronic liver disease. J Hepatol. 2023 Oct;79(4):885-887. Epub 2023 Jul 28.

13.07.23

Kleinehr J, Schöfbänker M, Daniel K, Günl F, Mohamed FF, Janowski J, Brunotte L, Boergeling Y, Liebmann M, Behrens M, Gerdemann A, Klotz L, Esselen M, Humpf HU, Ludwig S, Hrincius ER. Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA. PLoS Pathog. 2023 Jul 13;19(7):e1010986. doi: 10.1371/journal.ppat.1010986. 

03.07.23

Zarbock A, Koyner JL, Gomez H, Pickkers P, Forni L; ADQI group. Sepsis- associated acute kidney injury – treatment standard. Nephrol Dial Transplant. 2023 Jul 3: Epub ahead of print. 

02.06.23

Zurek-Leffers FM, Lehmann F, Brabenec L, Kintrup S, Hellenthal KEM, Mersjann K, Kneifel F, Hessler M, Arnemann PH, Kampmeier TG, Ertmer C, Kellner P, Wagner NM. A model of porcine polymicrobial septic shock. Intensive Care Med Exp. 2023 Jun 2;11(1):31. doi: 10.1186/s40635-023-00513-7.

15.05.23

Drost CC, Unger A, Linke WA, Vink H, Kümpers P. The dynamics of the endothelial glycocalyx: a rare snapshot by electron microscopy. Angiogenesis. 2023 May 15:1–5. doi: 10.1007/s10456-023-09880-x. Epub ahead of print.

09.05.23

Sadjadi M, Porschen C, von Groote T, Albert F, Kellum JA, Gomez H, Meersch M, Zarbock A. Implementation of Nephroprotective Measures to Prevent Acute Kidney Injury in Septic Patients: A Retrospective Cohort Study. Anesth Analg. 2023 May 9. doi: 10.1213/ANE.0000000000006495.

28.04.23

Möller A, Jauch-Speer SL, Gandhi S, Vogl T, Roth J, Fehler O. The roles of toll-like receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for monocyte activation by the DAMP S100A8/S100A. Front Immunol. 2023 Mar 28;14:1110185. doi: 10.3389/fimmu.2023.1110185.

05.04.23

Vöing K, Michgehl U, Mertens ND, Picciotto C, Maywald ML, Goretzko J, Waimann S, Gilhaus K, Rogg M, Schell C, Klingauf J, Tsytsyura Y, Hansen U, van Marck V, Edinger AL, Vollenbröker B, Rescher U, Braun DA, George B, Weide T, Pavenstädt H. Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy. J Am Soc Nephrol. 2023 Apr 5. doi: 10.1681/ASN.0000000000000126.

29.03.23

Meersch M, Weiss R, Gerss J, Albert F, Gruber J, Kellum JA, Chawla L, Forni LG, Koyner JL, von Groote T, Zarbock A. Predicting the Development of Renal Replacement Therapy Indications by Combining the Furosemide Stress Test and Chemokine (C-C Motif) Ligand 14 in a Cohort of Postsurgical Patients. Crit Care Med. 2023 Mar 29. doi: 10.1097/CCM.0000000000005849.

28.03.23

Weiss R, von Groote T, Ostermann M, Lumlertgul N, Weerapolchai K, Garcia MIM, Cano JMM, Del Corral BD, Broch-Porcar MJ, Perez Carrasco M, De la Vega Sanchez A, Sousa E, Catarino A, Roig AJB, Martinez de Irujo JB, de Rosa S, de la Peña MG, Tomasa T, Brivio M, De Molina FJG, Gerss J, Kellum JA, Wempe C, Leidereiter A, Meersch M, Zarbock A. The Role of Cell Cycle Arrest Biomarkers for Predicting Acute Kidney Injury in Critically Ill COVID-19 Patients: A Multicenter, Observational Study. Crit Care Med. 2023 Mar 28. doi: 10.1097/CCM.0000000000005853.

27.03.23

von Groote T, Meersch M, Romagnoli S, Ostermann M, Ripollés-Melchor J, Schneider AG, Vandenberghe W, Monard C, De Rosa S, Cattin L, Rahmel T, Adamzik M, Parise D, Candela-Toha A, Haaker JG, Göbel U, Bernard A, Lumlertgul N, Fernández-Valdes-Bango P, Romero Bhathal I, Suarez-de-la-Rica A, Larmann J, Villa G, Spadaro S, Wulf H, Arndt C, Putensen C, García-Álvarez R, Brandenburger T, Siniscalchi A, Ellerkmann R, Espeter F, Porschen C, Sadjadi M, Saadat-Gilani K, Weiss R, Gerss J, Kellum J, Zarbock A; BigpAK-2 Investigators. Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial. BMJ Open. 2023 Mar 27;13(3):e070240. doi: 10.1136/bmjopen-2022-070240.

13.03.23

de Melo BMS, Veras FP, Zwicky P, Lima D, Ingelfinger F, Varela T, da Silva Prado D, Schärli S, Publio G, Hiroki CH, Melo PH, Saraiva A, Norbiato T, Lima L, Ryffel B, Vogl T, Roth J, Waisman A, Nakaya HI, da Silva Souza C, Cunha FQ, Cunha TM, Becher B, Alves-Filho JC. S100A9 drives the chronification of psoriasiform inflammation by inducing IL-23/type 3 immunity. J Invest Dermatol. 2023 Mar 13:S0022-202X(23)01825-0. doi: 10.1016/j.jid.2023.02.026.

13.03.23

Lin C, Garcia-Gerique L, Bonner EE, Mastio J, Rosenwasser M, Cruz Z, Lawler M, Bernabei L, Muthumani K, Liu Q, Poncz M, Vogl T, Törngren M, Eriksson H, Vogl DT, Gabrilovich DI, Nefedova Y. S100A8/S100A9 Promote Progression of Multiple Myeloma via Expansion of Megakaryocytes. Cancer Res Commun. 2023 Mar 13;3(3):420-430. doi: 10.1158/2767-9764.CRC-22-0368.

11.03.23

Schulz A, Drost CC, Hesse B, Beul K, Boeckel GR, Lukasz A, Pavenstädt H, Brand M, Di Marco GS. Y. The Endothelial Glycocalyx as a Target of Excess Soluble Fms-like Tyrosine Kinase-1. Int J Mol Sci. 2023 Mar 11;24(6):5380. doi: 10.3390/ijms24065380.

09.03.23

Wolf M, Joseph R, Austermann J, Scharrnbeck-Davis C, Hermann S, Roth J, Vogl T. S100A8/S100A9 Integrates F-Actin and Microtubule Dynamics to Prevent Uncontrolled Extravasation of Leukocytes. Biomedicines. 2023 Mar 9;11(3):835. doi: 10.3390/biomedicines11030835.

28.02.23

Vom Werth KL, Kemper B, Kampmeier S, Mellmann A. Application of Digital Holographic Microscopy to Analyze Changes in T-Cell Morphology in Response to Bacterial Challenge. Cells. 2023 Feb 28;12(5):762. doi: 10.3390/cells12050762

23.02.23

Ludwig S, Pleschka S, Planz O. MEK inhibitors as novel host-targeted antivirals with a dual-benefit mode of action against hyperinflammatory respiratory viral diseases. Curr Opin Virol. 2023 Feb 23;59:101304. doi: 10.1016/j.coviro.2023.101304.

23.02.23

Zarbock A, Nadim MK, Pickkers P, Gomez H, Bell S, Joannidis M, Kashani K, Koyner JL, Pannu N, Meersch M, Reis T, Rimmelé T, Bagshaw SM, Bellomo R, Cantaluppi V, Deep A, De Rosa S, Perez-Fernandez X, Husain-Syed F, Kane-Gill SL, Kelly Y, Mehta RL, Murray PT, Ostermann M, Prowle J, Ricci Z, See EJ, Schneider A, Soranno DE, Tolwani A, Villa G, Ronco C, Forni LG. Sepsis-associated acute kidney injury: consensus report of the 28th Acute Diseases Quality Initiative workgroup. Nat Rev Nephrol. 2023 Feb 23. doi: 10.1038/s41581-023-00683-3.

21.02.23

Jorch SK, McNally A, Berger P, Wolf J, Kaiser K, Chetrusca Covash A, Robeck S, Pastau I, Fehler O, Jauch-Speer SL, Hermann S, Schäfers M, Van Gorp H, Kanneganti A, Dehoorne J, Haerynck F, Penco F, Gattorno M, Chae JJ, Kubes P, Lamkanfi M, Wullaert A, Sperandio M, Vogl T, Roth J, Austermann J. Complex regulation of alarmins S100A8/A9 and secretion via Gasdermin-D pores exacerbates autoinflammation in Familial Mediterranean Fever. J Allergy Clin Immunol. 2023 Feb 21:S0091-6749(23)00225-7. doi: 10.1016/j.jaci.2023.01.037.

18.02.23

Haeberle H, Calov S, Martus P, Serna-Higuita LM, Koeppen M, Goll A, Bernard A, Zarbock A, Meersch M, Weiss R, Mehrländer M, Marx G, Putensen C, Bakchoul T, Maguina H, Nieswandt B, Mirakaj V, Rosenberger P. Inhaled prostacyclin therapy in the acute respiratory distress syndrome: a randomized controlled multicenter trial. Respir Res. 2023 Feb 18;24(1):58. doi: 10.1186/s12931-023-02346-0.

13.02.23

Limmer A, Engler A, Kattner S, Gregorius J, Pattberg KT, Schulz R, Schwab J, Roth J, Vogl T, Krawczyk A, Witzke O, Zelinskyy G, Dittmer U, Brenner T, Berger MM. Patients with SARS-CoV-2-Induced Viral Sepsis Simultaneously Show Immune Activation, Impaired Immune Function and a Procoagulatory Disease State. Vaccines (Basel). 2023 Feb 13;11(2):435. doi: 10.3390/vaccines11020435.

11.02.23

Günl F, Krischuns T, Schreiber JA, Henschel L, Wahrenburg M, Drexler HCA, Leidel SA, Cojocaru V, Seebohm G, Mellmann A, Schwemmle M, Ludwig S, Brunotte L. The ubiquitination landscape of the influenza A virus polymerase. Nat Commun. 2023 Feb 11;14(1):787. doi: 10.1038/s41467-023-36389-0. PMID: 36774438; PMCID: PMC9922279.

10.02.23

Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H. Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. Science. 2023 Feb 10;379(6632):586-591. doi: 10.1126/science.add0875.

06.02.23

Shirakura K, Baluk P, Nottebaum AF, Ipe U, Peters KG, McDonald DM, Vestweber D. Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration. EMBO Mol Med. 2023. Feb 6;e16128. doi: 10.15252/emmm.202216128.

12.01.23

Hosseinnejad A, Ludwig N, Mersmann S, Winnerbach P, Bleilevens C, Rossaint R, Rossaint J, Singh S. Bioactive nanogels mimicking the antithrombotic nitric oxide-release function of the endothelium. Small. 2023 Jan 12:e2205185. doi: 10.1002/smll.202205185.

08.12.22

Regier M, Drost CD, Rauen M, Pavenstädt H, Rovas A, Kümpers P, Vink H, Long RM, Linke WA, Nofer JR, Lukasz AH. A dietary supplement containing fucoidan preserves endothelial glycocalyx through ERK/MAPK signaling and protects against damage induced by CKD serum. Int J Mol Sci. 2022, 23, 15520. doi: 10.3390/ijms232415520.  

07.12.22

Jin Y, Ding Y, Richards M, Kaakinen M, Giese W, Baumann E, Szymborska A, Rosa A, Nordling S, Schimmel L, Akmeriç EB, Pena A, Nwadozi E, Jamalpour M, Holstein K, Sáinz-Jaspeado M, Bernabeu MO, Welsh M, Gordon E, Franco CA, Vestweber D, Eklund L, Gerhardt H, Claesson-Welsh L. Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis. Nat Cardiovasc Res. 2022 Dec 7;1(12):1156-1173. doi: 10.1038/s44161-022-00172-z. 

06.12.22

Revenstorff J, Ludwig N, Hilger A, Mersmann S, Lehmann M, Grenzheuser JC, Kardell M, Bone J, Kötting NM, Marx NC, Roth J, Vogl T, Rossaint J. Role of S100A8/A9 in Platelet-Neutrophil Complex Formation during Acute Inflammation. Cells. 2022 Dec 6;11(23):3944. doi: 10.3390/cells11233944. 

06.12.22

He S, Zambelli VO, Sinharoy P, Brabenec L, Bian Y, Rwere F, Hell RC, Stein Neto B, Hung B, Yu X, Zhao M, Luo Z, Wu C, Xu L, Svensson KJ, McAllister SL, Stary CM, Wagner NM, Zhang Y, Gross ER. A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents. J Clin Invest. 2022 Dec 6:e163735. doi:10.1172/JCI163735.

29.11.22

Weiss R, Meersch M, Gerke M, Wempe C, Schäfers M, Kellum JA, Zarbock A. Effect of Glutamine Administration After Cardiac Surgery on Kidney Damage in Patients at High Risk for Acute Kidney Injury: A Randomized Controlled Trial. Anesth Analg. 2022. Nov 29. 

21.11.22

Faist A, Schloer S, Mecate-Zambrano A, Janowski J, […], Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L. 2022. Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier. Antiviral Res 105475. 2022/11/25, 10.1016/j.antiviral.2022.105475.

31.10.22

von Groote T, Albert F, Meersch M, Koch R, Porschen C, Hartmann O, Bergmann D, Pickkers P, Zarbock A. Proenkephalin A 119-159 predicts early and successful liberation from renal replacement therapy in critically ill patients with acute kidney injury: a post hoc analysis of the ELAIN trial. Crit Care. 2022 Oct 31;26(1):333. doi: 10.1186/s13054-022-04217-4.

30.10.22

Russo A, Schürmann H, Brandt M, Scholz K, Matos AL, Grill D, Revenstorff J, Rembrink M, […] Hermann S, Klotz L, Gerke V, Betz T, Vogl T, Roth J. Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes. Adv Sci (Weinh). 2022 Oct 30;e2201505. doi: 10.1002/advs.202201505. Epub ahead of print.

14.10.22

Schenz J, Rump K, Hermann Siegler B, […] von Groote T, Zarbock A, Fiedler MO, Zemva J, Larmann J, Merle U, Adamzik M, Müller-Tidow C, Haferlach T, Leuschner F, Weigand MA. Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19. Front Immunol. 2022 Oct 14;13:968778. doi:10.3389/fimmu.2022.968778. eCollection 2022.

29.09.22

von Groote T, Meersch-Dini M. Biomarkers for the Prediction and Judgement of Sepsis and Sepsis Complications: A Step towards precision medicine? J. Clin. Med. 2022, 11(19), 5782; https://doi.org/10.3390/jcm11195782

15.09.22

Thomas K, Zondler L, Ludwig N, Kardell M, Lüneburg C, Henke K, Mersmann S, Margraf A, […] Meersch M, Vestweber D, Westphal M, Roth J, Schaefers MA, Kellum JA, Lowell CA, Rossaint J, Zarbock A. Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells. JCI Insight. 2022 Sep 15;e163161. doi: 10.1172/jci.insight.163161. Epub ahead of print.

05.09.22

Lehmann M, Zarbock  A, Rossaint J. New aspects of perioperative organ protection. Anaesthesiologie. 2022. doi: 10.1007/s00101-022-01197-6. Epub ahead of print.

25.08.22

Schreiber A, Ambrosy B, Planz O, Schloer S, Rescher U, Ludwig S. The MEK1/2 Inhibitor ATR-002 (Zapnometinib) Synergistically Potentiates the Antiviral Effect of Direct-Acting Anti-SARS-CoV-2 Drugs. Pharmaceutics. 2022 Aug 25;14(9):1776. doi: 10.3390/pharmaceutics14091776.

24.08.22

Schloer S, Treuherz D, Faist A, de Witt M, Wunderlich K, Wiewrodt R, Wiebe K, Barth P, Wälzlein JH, Kummer S, Balkema-Buschmann A, Ludwig S, Brunotte L, Rescher U. 3D ex vivo tissue platforms to investigate the early phases of influenza A virus- and SARS-CoV-2-induced respiratory diseases. Emerg Microbes Infect. 2022 Aug 24;1-30. doi: 10.1080/22221751.2022.2117101. Epub ahead of print.

20.08.22

Brabenec L, Hellenthal KEM, Müller M, Kintrup S, Zurek-Leffers F, Kardell M, Otto M, Wagner NM. Procalcitonin mediates vascular dysfunction in obesity. Life Sci. 2022 Aug 20;307:120889. doi: 10.1016/j.lfs.2022.120889. Epub ahead of print.

15.08.22

Brabenec L, Müller M, Hellenthal KEM, Karsten OS, Pryvalov H, Otto M, […] Margraf A, Nottebaum AF, Rossaint J, Zarbock A, Vestweber D, Gerke V, Wagner NM. Targeting Procalcitonin Protects Vascular Barrier Integrity. Am J Respir Crit Care Med. 2022 Aug 15;206(4):488-500.

11.08.22

Osiaevi I, Schulze A, Evers G, Harmening K, Vink H, Kümpers P, Mohr P, Rovas A. Persistent capillary rarefication in long COVID syndrome. Angiogenesis. 2022 Aug 11;1-9. doi: 10.1007/s10456-022-09850-9. Epub ahead of print.

01.08.22

Wienkamp  AK, Erpenbeck L, Rossaint J. Platelets in the NETworks interweaving inflammation and thrombosis. Front Immunol. 2022 Aug 1;13:953129. doi: 10.3389/fimmu.2022.953129. eCollection 2022.

14.07.22

Faist A, Janowski J, Kumar S, Hinse S, Çalışkan DM, Lange J, Ludwig S, Brunotte L. Virus Infection and Systemic Inflammation: Lessons Learnt from COVID-19 and Beyond. Cells 2022, 11(14), 2198; doi.org/10.3390/cells11142198

08.07.22

Schütte-Nütgen K, Edeling M, Kentrup D, Heitplatz B, Van Marck V, Zarbock A, Meersch-Dini M, Pavenstädt H, Reuter S. Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury. Am J Transplant. 2022 Jul 8. doi: 10.1111/ajt.17143. Epub ahead of print.

06.07.22

Aulin C, Larsson S, Vogl T, Roth J, Åkesson A, Swärd P, Heinbäck R, Erlandsson Harris H, Struglics A. The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury. Osteoarthritis Cartilage. 2022 Jul 6;S1063-4584(22)00773-7. doi: 10.1016/j.joca.2022.06.009. Epub ahead of print.

29.06.22

Mildner K, Breitsprecher L, Currie SM, Stegmeyer RI, Stasch M, Volkery S, Psathaki OE, Vestweber D, Zeuschner D. Landmark-based retrieval of inflamed skin vessels enabled by 3D correlative intravital light and volume electron microscopy. Histochem Cell Biol. 2022 Jun 29. doi: 10.1007/s00418-022-02119-8. Epub ahead of print.

21.06.22

Rossaint J, Meersch M, Thomas K, Mersmann S, Lehmann M, Skupski J, Tekath T, Rosenberger P, Kellum JA, Pavenstädt H, Zarbock A. Remote ischemic preconditioning causes transient cell-cycle arrest and renal protection by a NF-kB-dependent Sema5B pathway. JCI Insight. 2022 Jun 21;e158523. doi: 10.1172/jci.insight.158523. Online ahead of print.

21.06.22

Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, […], Ludwig S, Suttorp N, Witzenrath M, Gruber AG, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC. Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages. Eur Respir J. 2022 Jun 21;2102725. doi:10.1183/13993003.02725-2021. Epub ahead of print.

20.06.22

Austermann J, Roth J, Barczyk-Kahlert K. The Good and the Bad: Monocytes‘ and Macrophages‘ Diverse Functions in Inflammation. Cells. 2022 Jun 20;11(12):1979. doi: 10.3390/cells11121979.

20.06.22

Rovas A, Buscher K, Osiaevi I, Drost CC, Sackarnd J, Tepasse PR, Fobker M, Kühn J, Braune S, Göbel U, Thölking G, Gröschel A, Rossaint J, Vink H, Lukasz A, Pavenstädt H, Kümpers P. Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study. Angiogenesis. 2022 Jun 20;1-13. doi: 10.1007/s10456-022-09843-8. Epub ahead of print.

17.06.22

Ludwig N, Hilger A, Zarbock A, Rossaint J. Platelets at the Crossroads of Pro-Inflammatory and Resolution Pathways during Inflammation. Cells 2022, 11(12), 1957; https://doi.org/10.3390/cells11121957

15.06.22

Hellenthal KEM, Brabenec L, Wagner NM. Regulation and Dysregulation of Endothelial Permeability during Systemic Inflammation. Cells 2022, 11(12), 1935; https://doi.org/10.3390/cells1112193

14.06.22

Block H, Rossaint J, Zarbock A. The Fatal Circle of NETs and NET-Associated DAMPs Contributing to Organ Dysfunction. Cells. 2022 Jun 14;11(12):1919.doi: 10.3390/cells11121919.

14.06.22

Brabenec L, Müller M, Hellenthal KE, Karsten OS, Pryvalov H, Otto M, Holthenrich A, Linard Matos AL, Weiss R, Kintrup S, Hessler M, Dell’Aquila A, Thomas K, Naß J, Margraf A, Nottebaum AF, Rossaint J, Zarbock A, Vestweber D, Gerke V, Wagner NM. Targeting Procalcitonin Protects Vascular Barrier Integrity. Am J Respir Crit Care Med. 2022 Jun 14.doi: 10.1164/rccm.202201-0054OC. Epub ahead of print.

10.06.22

Drost CC, Rovas A, Osiaevi I, Rauen M, van der Vlag J, Buijsers B, Salmenov R, Lukasz A, Pavenstädt H, Linke WA, Kümpers P. Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study. Front Immunol. 2022 Jun 10;13:916512. doi: 10.3389/fimmu.2022.916512. eCollection 2022.

04.06.22

Meersch M, Weiss R, Küllmar M, Bergmann L, Thompson A, Griep L, Kusmierz D, Buchholz A, Wolf A, Nowak H, Rahmel T, Adamzik M, […], Gerß J, Sessler DI, Wempe C, Massoth C, Zarbock A. Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications Among Adults: The HandiCAP Randomized Clinical Trial. JAMA. 2022 Jun 4. doi: 10.1001/jama.2022.9451. Epub ahead of print.

01.06.22

Margraf A, Liu L, Küllmar M, Meersch M, Rossaint, Zarbock A. Analysis of Leukocyte Recruitment in Continuous Veno-Venous Hemofiltration with Regional Citrate vs. Systemic Heparin Anticoagulation. Cells. 2022 Jun 1;11(11):1815.doi: 10.3390/cells11111815.

15.05.22

Schürmann H, Abbasi F, Russo A, Hofemeier AD, Brandt M, Roth J, Vogl T, Betz T. Analysis of monocyte cell tractions in 2.5D reveals mesoscale mechanics of podosomes during substrate-indenting cell protrusion. J Cell Sci. 2022 May 15;135(10):jcs259042. doi: 10.1242/jcs.259042.

13.05.22

Gerss J, Meersch M, Kindgen-Milles D, Brandenburger T, Willam C, Kellum JA, Zarbock A, RICH investigators. The Effect of Filter Lifespan during Continuous Renal Replacement Therapy in Critically Ill Patients with AKI on the Rate of New Onset Infection: Analysis from the RICH Randomized Controlled Trial. Am J Respir Crit Care Med. 2022 May 13. doi: 10.1164/rccm.202201-0063LE. Epub ahead of print.

11.05.22

Jauch-Speer SL, Herrera-Rivero M, Ludwig N, Véras De Carvalho BC, Martens L, Wolf J, Chasan AI, Witten A, Markus B, Schieffer B, Vogl T, Rossaint J, Stoll M, Roth J, Fehler O. C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9. Elife. 2022 May 11;11:e75594. doi: 10.7554/eLife.75594. Epub ahead of print.

21.04.22

Li Z, Ludwig N, Thomas K, Mersmann S, Lehmann M, Vestweber D, Pittet JF, Gomez H, Kellum JA, Rossaint J, Zarbock, A. The Pathogenesis of Ischemia-Reperfusion Induced Acute Kidney Injury Depends on Renal Neutrophil Recruitment Whereas Sepsis-Induced AKI Does Not. Front Immunol. 2022 Apr 21;13:843782. doi: 10.3389/fimmu.2022.843782. eCollection 2022.

12.04.22

Cappenberg A, Kardell M, Zarbock A. Selectin-Mediated Signaling-Shedding Light on the Regulation of Integrin Activity in Neutrophils. Cells. 2022 Apr 12;11(8):1310. doi: 10.3390/cells11081310.

01.04.22

Zarbock A, Buhre W. Hydroxyethyl Starch in the Perioperative Period: Friend, Foe, or Still an Unsolved Issue? Anesth Analg. 2022 Apr 1;134(4):683-685. doi: 10.1213/ANE.0000000000005903.

31.03.22

Currie SM, Stegmeyer R, Mildner K, Breitsprecher L, Zeuschner D, Psathaki OE, Schäfer K, Wilkens M, Volkery S, Nieswandt B, Vestweber D. Confocal Real-Time Analysis of Cutaneous Platelet Recruitment during Immune-Complex-Mediated Inflammation. J Invest Dermatol. 2022 Mar 31;S0022-202X(22)00254-8. doi: 10.1016/j.jid.2022.03.011. Epub ahead of print.

08.03.22

Menuchin-Lasowski Y, Schreiber A, Lecanda A, Mecate-Zambrano A, Brunotte L, Psathaki OE, Ludwig S, Rauen T, Schöler HR. SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids. Stem Cell Reports. 2022 Mar 8; S2213-6711(22)00104-7.doi: 10.1016/j.stemcr.2022.02.015. Epub ahead of print.

22.02.22

Schuhenn J, Meister TL, […] Brunotte L, […] Ludwig S, Sitek B, Steinmann E, Dittmer U, Lavender KJ, Sutter K, Pfaender S. Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection. Proc Natl Acad Sci U S A,. 2022 Feb 22;119(8):e2111600119. doi: 10.1073/pnas.2111600119.

21.02.22

Kielstein JT, Zarbock A. Is This the Beginning of the End of Cytokine Adsorption? Crit Care Med. 2022 Feb 21. doi: 10.1097/CCM.0000000000005509. Epub ahead of print.

16.02.22

Meersch M, Weiss R, Massoth C, Küllmar M, Saadat-Gilani K, Busen M, Chawla L, Landoni G, Bellomo R, Gerss J, Zarbock A. The Association Between Angiotensin II and Renin Kinetics in Patients After Cardiac Surgery. Anesth Analg. 2022 Feb 16. doi: 10.1213/ANE.0000000000005953. Epub ahead of print.

08.02.22

Vom Werth KL, Wörmann T, Kemper B, Kümpers P, Kampmeier S, Mellmann A. Investigating Morphological Changes of T-lymphocytes after Exposure with Bacterial Determinants for Early Detection of Septic Conditions. Microorganisms. 2022 Feb 8;10(2):391. doi: 10.3390/microorganisms10020391.

08.02.22

Conrad C, Yildiz D, Cleary SJ, Margraf A, […],Eltzschig HK, CAPSys Study Group; Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight. 2022 Feb 8;7(3):e149870. doi: 10.1172/jci.insight.149870.

10.01.22

Schreiber A, […] Brunotte L, Faist A, Schöfbänker M, Hrincius E, Hoffmann H, Hoffmann M, Pöhlmann S, Rescher U, Planz O, Ludwig S, The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses. Cell Mol Life Sci. 2022 Jan 10;79(1):65.doi: 10.1007/s00018-021-04085-1.

30.12.21

Weiss R, Saadat-Gilani K, Kerschke L, Wempe C, Meersch M, Zarbock A, EPIS-AKI Investigators. EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial. BMJ Open. 2021 Dec 30;11(12):e055705. doi: 10.1136/bmjopen-2021-055705.

18.12.21

Von Groote TC, Ostermann M, Forni LG, Meersch-Dini M, Zarbock A, PrevAKI Investigators, The AKI care bundle: all bundle components are created equal-are they? Intensive Care Med. 2021 Dec 18. doi: 10.1007/s00134-021-06601-0. Epub ahead of print.

14.12.21

Steiger S, Rossaint J, Zarbock A, Anders HJ, Secondary Immunodeficiency Related to Kidney Disease (SIDKD) – Definition, Unmet Need and Mechanisms. J Am Soc Nephrol. 2021 Dec 14;ASN.2021091257. doi: 10.1681/ASN.2021091257. Epub ahead of print.

15.11.21

Li Z, Tie H, Shi R, Rossaint J, Zarbock A, Urinary [TIMP-2]·[IGFBP7]-guided implementation of the KDIGO bundle to prevent acute kidney injury: a meta-analysis. Br J Anaesth. 2021 Nov 15;S0007-0912(21)00685-1. doi: 10.1016/j.bja.2021.10.015. Epub ahead of print.

14.11.21

Zarbock A, Chawla L, Bellomo R, Why the renin-angiotensin-aldosterone system (RAAS) in critically ill patients can no longer be ignored. Crit Care. 2021 Nov 14;25(1):389. doi: 10.1186/s13054-021-03816-x.

03.11.21

Drost CD, Rovas A, Kümpers P, Protection and rebuilding of the endothelial glycocalyx in sepsis – Science or fiction? Matrix Biol Plus. 2021 Nov 3;12:100091. doi: 10.1016/j.mbplus.2021.100091.

22.10.21

Kruisbergen NNL, Ceglie ID, van Gemert Y, […], Roth J, Vogl T, van der Kraan PM, Blom AB, van Lent PLM, van den Bosch MHJ, Nox 2 Deficiency Reduces Cartilage Damage and Ectopic Bone Formation in an Experimental Model for Osteoarthritis. Antioxidants (Basel). 2021 Oct 22;10(11):1660. doi: 10.3390/antiox10111660.

14.10.21

Kleinehr J, Wilden JJ, Boergeling Y, Ludwig S, Hrincius ER, Metabolic Modifications by Common Respiratory Viruses and Their Potential as New Antiviral Targets. Viruses 2021 Oct 14;13(10):2068.doi: 10.3390/v13102068.

08.10.21

Margraf A, Lowell CA, Zarbock A, Neutrophils in acute inflammation – current concepts and translational implications. Blood 2021 Oct 8;blood.2021012295. doi: 10.1182/blood.2021012295. Epub ahead of print.

01.10.21

Zarbock A, The Journey Begins: Personalized Acute Kidney Injury Therapy. Crit Care Med. 2021 Oct 1;49(10):1822-1825. doi: 10.1097/CCM.0000000000005100. Epub ahead of print

01.10.21

Kumar S, Çalışkan DM, Janowski J, Faist A, Conrad BCG, Lange J, Ludwig S, Brunotte L, Beyond Vaccines: Clinical Status of Prospective COVID-19 Therapeutics, Front Immunol. 2021 Oct 1;12:752227. doi: 10.3389/fimmu.2021.752227. eCollection 2021.

24.09.21

Hellenthal KEM, Brabenec L, Gross ER, Wagner NM, TRP Channels as Sensors of Aldehyde and Oxidative Stress. Biomolecules 2021 Sep 24;11(10):1401. doi: 10.3390/biom11101401.

22.09.21

Günl F, Mecate-Zambrano A, Rehländer S, Hinse S, Ludwig S, Brunotte L, Shooting at a Moving Target—Effectiveness and Emerging Challenges for SARS-CoV-2 Vaccine Development. Vaccines 2021, 9(10), 1052. Epub ahead of print

15.09.21

Saadat-Gilani K, Zarbock A, Perioperative renal protection. Curr Opin Crit Care. 2021 Sep 15. doi: 10.1097/MCC.0000000000000881.

07.09.21

Nacken W, Schreiber A, Masemann D, Ludwig S, The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus. mBio. 2021 Sep 7;e0219621. doi: 10.1128/mBio.02196-21. Epub ahead of print

03.09.21

Brunotte L, Zheng S, Mecate-Zambrano A, Tang J, Ludwig S, Rescher U, Schloer S, Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro. Pharmaceutics 2021, 13(9), 1400. Epub ahead of print.

01.09.21

Otto M, Brabenec L, Müller M, Kintrup S, Hellenthal KEM, Holtmeier R, Steinbuch SC, Karsten OS, Pryvalov H, Rossaint J, Gross ER, Wagner NM, Development of heart failure with preserved ejection fraction in type 2 diabetic mice is ameliorated by preserving vascular function. Life Sci. 2021 Sep 1;119925. doi: 10.1016/j.lfs.2021.119925. Epub ahead of print.

15.07.21

Kellum JA, Romagnani P, Ashuntantang G, Ronco C, Zarbock A, Anders HJ, Acute kidney injury. Nat Rev Dis Primers. 2021 Jul 15;7(1):52. doi: 10.1038/s41572-021-00284-z.

02.06.21

Buscher K, Heitplatz B, van Marck V, Song J, Loismann S, Rixen R, Hüchtmann B, Kurian S, Ehinger E, Wolf D, Ley K, Pavenstädt H, Reuter S. Data-Driven Kidney Transplant Phenotyping as a Histology-Independent Framework for Biomarker Discovery. J Am Soc Nephrol. 2021 Aug;32(8):1933-1945. doi: 10.1681/ASN.2020121685. Epub 2021 Jun 2. 

01.06.21

Boergeling Y, Brunotte L, Ludwig S, Dynamic phospho-modification of viral proteins as a crucial regulatory layer of influenza A virus replication and innate immune responses. Biol Chem. 2021 Jun 1. doi: 10.1515/hsz-2021-0241. Epub ahead of print.

24.05.21

Ackermann M, Anders HJ, […], Zarbock A, Schett G, Herrmann M, Patients with COVID-19: in the dark-NETs of neutrophils. Cell Death Differ. 2021 May 24;1-15. doi: 10.1038/s41418-021-00805-z. Epub ahead of print.

20.05.21

Rossaint J, Thomas K, Mersmann S, Skupski J, Margraf A, Tekath T, Jouvene CC, Dalli J, Hidalgo A, Meuth SG, Soehnlein O, Zarbock A, Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education. J Exp Med. 2021 Jul 5;218(7):e20201353. doi: 10.1084/jem.20201353. Epub ahead of print.

01.05.21

Küllmar M, Saadat-Gilani K, Weiss R, Massoth C, Lagan A, Cortés MN, Gerss J, Chawla LS, Fliser D, Meersch M, Zarbock A. Kinetic Changes of Plasma Renin Concentrations Predict Acute Kidney Injury in Cardiac Surgery Patients. Am J Respir Crit Care Med. 2021 May 1;203(9):1119-1126. doi: 10.1164/rccm.202005-2050OC.

28.04.21

Ninchoji T, Love DT, Smith RO, Hedlund M, Vestweber D, Sessa WC, Welsh LC, eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin. Elife. 2021 Apr 28;10:e64944. doi: 10.7554/eLife.64944.

05.04.21

Pirr S, Dauter L, Vogl T, Ulas T, Bohnhorst B, Roth J, Viemann D, S100A8/A9 is the first predictive marker for neonatal sepsis. Clin Transl Med. 2021 Apr;11(4):e338. doi: 10.1002/ctm2.338.

19.03.21

Rovas A, Sackarnd J, Rossaint J, Kampmeier S, Pavenstädt H, Vink H, Kümpers P. Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study. Crit Care. 2021 Mar 19;25(1):112. doi: 10.1186/s13054-021-03520-w.

11.03.21

Bertoglio F, Meier D, […], Brunotte L, Ludwig S, Fühner V, Krämer ST, Dübel S, Varani L, Roth G, Čičin-Šain L, Schubert M, Hust M. SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface. Nat. Commun. 2021 Mar 11;12(1):1577. doi: 10.1038/s41467-021-21609-2.

10.03.21

Massoth C, Küllmar M, Enders D, Kellum JA, Forni LG, Meersch M, Zarbock A, Progressive AKI Group, Comparison of C-C motif chemokine ligand 14 with other biomarkers for adverse kidney events after cardiac surgery. J Thorac Cardiovasc Surg. 2021 Mar 10;S0022-5223(21)00436-0. doi: 10.1016/j.jtcvs.2021.03.016. ePub ahead of print.

04.03.21

Hoffmann M […],Ludwig S, Noé F, Kjolby M, Braun A, Sheltzer JM, Pöhlmann S, Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. EBioMedicine. 2021 Mar;65:103255. doi: 10.1016/j.ebiom.2021.103255. Epub 2021 Mar 4.

02.03.21

Tran GVQ, Kleinehr J, Preugschas HF, Anhlan D, Mohamed FF, Ehrhardt C, Ludwig S, Hrincius ER, Nonsense-mediated mRNA decay does not restrict influenza A virus propagation. Cell Microbiol. 2021 Mar 2. doi: 10.1111/cmi.13323. ePub ahead of print

01.03.21

Vestweber D. Vascular Endothelial Protein Tyrosine Phosphatase Regulates Endothelial Function. Physiology (Bethesda). 2021 Mar 1;36(2):84-93. doi: 10.1152/physiol.00026.2020.

27.01.21

Schwierzeck V,  König JC, Kühn J, Mellmann A, Correa-Martínez CL, Omran H,  Konrad M, Kaiser T, Kampmeier S, First Reported Nosocomial Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 in a Pediatric Dialysis Unit. Clin Infect Dis. 2021 Jan 27;72(2):265-270. doi: 10.1093/cid/ciaa491

06.01.21

Patil A, Anhlan D,  Ferrando V, Mecate-Zambrano A, Mellmann A, Wixler V, Boergeling Y, Ludwig S, Phosphorylation of influenza A virus NS1 at serine 205 mediates its viral polymerase-enhancing function. J Virol. 2021 Jan 6;JVI.02369-20. ePub ahead of print

04.01.21

Ludwig S, Hrincius ER, Boergeling Y. The Two Sides of the Same Coin-Influenza Virus and Intracellular Signal Transduction. Cold Spring Harb Perspect Med. 2021 Jan 4;11(1):a038513. doi: 10.1101/cshperspect.a038513. 

15.12.20

Küllmar M, Saadat-Gilani K, Weiss R, Massoth C, Lagan A, Nunez Cortes M, Gerss J, Chawla LS, Fliser D, Meersch M, Zarbock A, Kinetic Changes of Plasma Renin Levels Predict Acute Kidney Injury in Cardiac Surgery Patients. Am J Respir Crit Care Med. 2020, Dec 15. ePub ahead of print

15.12.20

Wilden JJ, Hrincius ER, Niemann S, Boergeling Y, Löffler B, Ludwig S, Ehrhardt C, Impact of Staphylococcus aureus Small Colony Variants on Human Lung Epithelial Cells with Subsequent Influenza Virus Infection. Microorganisms. 2020, 8(12), 1998.

09.12.20

Schloer S, Brunotte L, Goretzko J , Mecate-Zambrano A, Korthals N, Gerke V, Ludwig S, Rescher U, Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine. Emerg Microbes Infect. 2020 Dec;9(1):2245-2255. doi: 10.1080/22221751.2020.1829082.

05.12.20

Masemann D, Ludwig S, Boergeling Y, Advances in Transgenic Mouse Models to Study Infections by Human Pathogenic Viruses. Int. J. Mol. Sci. 2020,21(23) 9289.

01.12.20

Saadat-Gilani K, Zarbock A, Meersch M, Perioperative Renoprotection: Clinical Implications. Anesth Analg. 2020 Dec;131(6):1667-1678.

19.11.20

Alon R, Sportiello M, Kozlovski S, Kumar A, Reilly EC, Zarbock A, Garbi N, Topham DJ, Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19. Nat Rev Immunol. 2020 Nov 19: 1–16. ePub ahead of print

23.10.20

Zarbock A, Küllmar M, Kindgen-Milles D […] Bagshaw SM, Kellum JA, Meersch M. Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial. JAMA. 2020 324(16):1629-1639.

21.10.20

Boff L, Schreiber A, da Rocha Matos A, Del Sarto J, Brunotte L […] Ludwig S. Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation. Molecules. 2020 Oct 21;25(20):E4853

15.10.20

Nadim MK, Forni LG, Mehta RL, Connor MJ Jr, Liu KD, Ostermann M, Rimmelé T, Zarbock A […] Kellum JA. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol. 2020, 16: 747-764.

14.10.20

Rovas A, Osiaevi I, Buscher K, Sackarnd J, Tepasse PR, Fobker M, Kühn J, Braune S, Göbel U, Thölking G, Gröschel A, Pavenstädt H, Vink H, Kümpers P. Microvascular dysfunction in COVID-19: the MYSTIC study. Angiogenesis. 2020 Oct 14:1-13. ePub ahead of print

06.10.20

Kane-Gill SL, Meersch M, Bell M. Biomarker-guided management of acute kidney injury. Curr Opin Crit Care. 2020, 26(6):556-562.

01.10.20

Ostermann M, Zarbock A, Goldstein S […] Shaw AD, Kellum JA, Ronco C. Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference: A Consensus Statement. JAMA Netw Open. 2020 Oct 1;3(10)e2019209.

28.09.20

Schloer S, Brunotte L, Goretzko J, Mecate-Zambrano A, Korthals N, Gerke V, Ludwig S, Rescher U. Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine. Emerg. Microbes Infect. 2020, 9(1): 2245-2255.

25.09.20

Meersch M, Zarbock A. Preemptive renal replacement therapy in critically ill patients? Ann. Transl. Med. 2020;8(16):978.

14.09.20

Küllmar M, Zarbock A, Engelmann DT, Chatterjee S, Wagner NM. Prevention of Acute Kidney Injury. Crit. Clin. 2020, 36(4):691-704.

09.09.20

Gerlach M , S Wolff S, Ludwig S, Schäfer W, Keiner B, Roth NJ, Widmer E, Rapid SARS-CoV-2 inactivation by commonly available chemicals on inanimate surfaces. J Hosp Infect. 2020 Nov;106(3):633-634. doi: 10.1016/j.jhin.2020.09.001. Epub 2020 Sep 9.

 

01.08.20

Meersch M, Küllmar M, Pavenstädt H, Rossaint J, Kellum JA, Martens S, Klausmeyer P, Schmidt EA, Kerschke L, Zarbock A, Effects of Different Doses of Remote Ischemic Preconditioning on Kidney Damage Among Patients Undergoing Cardiac Surgery: A Single-Center Mechanistic Randomized Controlled Trial. Crit Care Med. 2020 Aug;48(8):e690-e697.

14.07.20

Schreiber A, Boff L, Anhlan D, Krischuns T, Brunotte L, Schuberth C, Wedlich-Söldner R, Drexler H, Ludwig S. Dissecting the mechanisms of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes. PNAS. 2020 July 14;117(28):16557-16566.

12.07.20

Margraf A, Germena G, Drexler H, Rossaint J, Ludwig N, Prystaj B, Mersmann S, Thomas K, Block H, Gottschlich W, Liu C, Krenn P, Haller H, Heitplatz B, Meyer zu Brickwedde M, Moser M, Vestweber D, Zarbock A. The integrin linked kinase is required for chemokine-triggered high affinity conformation of neutrophil ß2-integrin LFA1. Blood. 2020, 136(19):2200-2205.

01.07.20

Ludwig S, Zarbock A, Coronaviruses and SARS-CoV-2: A Brief Overview. Anesth Analg. 2020 Jul;131(1):93-96. doi: 10.1213/ANE.0000000000004845.

29.06.20

Margraf A, Cappenberg A, Vadillo E, Ludwig N, Thomas K, Körner K, Zondler L, Rossaint J, Germena G, Hirsch E, Zarbock A. ArhGAP15, a RacGAP, acts as a temporal signaling regulator of Mac-1 affinity in sterile inflammation. J Immunol. 2020, 205(5): 1365-1375.

25.06.20

Otto M, Bucher C, Liu W, Müller M, Schmidt T, Kardell M, Driessen MN, Rossaint J, Gross ER, Wager NM. 12(S)-HETE mediates diabetes induced endothelial dysfunction by activating intracellular endothelial cell TRPV1. J Clin Invest. 2020 Sep 1;130(9):4999-5010.

08.06.20

Meersch M, Küllmar M, Pavenstädt H, Rossaint J, Kellum JA, Martens S, Klausmeyer P,  Schmidt EA, Kerschke L, Zarbock A. Effects of different doses of remote ischemic preconditioning on kidney damage among patients undergoing cardiac surgery – a single-center mechanistic randomized controlled trial. Critical Care Medicine. 2020 Aug;48(8):e690-e697.

06.05.20

Kehl A, Kuhn R, Detzner J, Steil D, Müthing J, Karch H, Mellmann A. Modeling native EHEC outer membrane vesicles by creating synthetic surrogates. Microorganisms. 2020 May 6;8(5):E673.

05.05.20

Braun LJ, Stegmeyer R, Schäfer K […] Kempe B, Nottebaum AF, Vestweber D. Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2. Blood. 2020 May 5.

27.04.20

Schwierzeck V, König JC, Kühn J, Mellmann A […] Konrad M, Kaiser T, Kampmeier S. First reported nosocomial outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a pediatric dialysis unit. Clin Infect Dis. 2020 Apr 27.

15.04.20

Laure M, Hamza H, Koch-Heier J […] Pleschka S, Ludwig S, Planz O. Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model. Antiviral Res. 2020 Apr 15;178:104806.

03.04.20

Correa-Martínez CL, Kampmeier S, Kümpers P […] Pavenstädt H, Ludwig S, Mellmann A. A pandemic in times of global tourism: superspreading and exportation of COVID-19 cases from a ski area in Austria. J Clin Microbiol. 2020 Apr 3.

01.04.20

Küllmar M, Weiß R, Ostermann M […] Wempe C, Meersch M, Zarbock A. A Multinational Observational Study Exploring Adherence With the Kidney Disease: Improving Global Outcomes Recommendations for Prevention of Acute Kidney Injury After Cardiac Surgery. Anesth Analg. 2020, 130(4), 910-916.

31.03.20

Ludwig S, Zarbock A. Coronaviruses and SARS-CoV-2: A Brief Overview. Anesth Analg. 2020 Mar;31.

19.03.20

Fischer-Riepe L, Daber N, Schulte-Schrepping J […] Schultze JL, Roth J, Barczyk-Kahlert K. CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow. J Allergy Clin Immunol. 2020 Mar 19. 

01.02.20

Schreiber A, Liedmann S, Brunotte L, Anhlan D, Ehrhardt C, Ludwig S. Type I interferon antagonistic properties of influenza B virus polymerase proteins. Cell Microbiol. 2020 Feb;22(2):e13143.

01.02.20

Liu W, Eczko JC, Otto M, Bajorat R, Vollmar B, Roesner JP, Wagner NM. Toll-like receptor 2-deficiency on bone marrow-derived cells augments vascular healing of murine arterial lesions. Life Sci. 2020 Feb 1;242:117189.

16.01.20

Lindemann O, Rossaint J, Najder K, Schimmelpfennig S, Hofschröer V, Wälte M, Fels B, Oberleithner H, Zarbock A, Schwab A. Intravascular adhesion and recruitment of neutrophils in response to CXCL1 depends on their TRPC6 channels. J Mol Med (Berl). 2020 Jan 16.

12.12.19

Duong CN, Nottebaum AF, Butz S, Volkery S, Zeuschner D, Stehling M, Vestweber D. Interference With ESAM (Endothelial Cell-Selective Adhesion Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate Lethality and Lung-Specific Blood Coagulation. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):378-393.

01.11.19

Drost CC, Rovas A, Kusche-Vihrog K, Van Slyke P, Kim H, Hoang VC, Maynes JT, Wennmann DO, Pavenstädt H, Linke W, Lukasz A, Hesse B, Kümpers P. Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis. Thromb Haemost. 2019 Nov;119(11):1827-1838.

01.07.19

Braun LJ, Zinnhardt M, Vockel M, Drexler HC, Peters K, Vestweber D. VE-PTP inhibition stabilizes endothelial junctions by activating FGD5. EMBO Rep. 2019 Jul;20(7):e47046.

01.01.19

Matos ADR, Wunderlich K, Schloer S […] Matera N, Ludwig S, Brunotte L. Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities. Emerg Microbes Infect. 2019;8(1):1763-1776.