Publikationen
Hier sind alle Publikationen der Klinischen Forschungsgruppe KFO342 zu finden. Die Publikationsliste wird in umgekehrt chronologischer Reihung geführt.
Publikationsliste
12.06.25
Cappenberg A, Oguama M, Richter M, Margraf A, Amini W, Lindental P, Mersmann S, Bardel B, Block H, Vogl T, Soehnlein O, Ley K, Rossaint J, Zarbock A. RhoA GAP Myo9b regulates β2-integrin activity and neutrophil recruitment during murine acute kidney injury. Blood. 2025 Jun 12:blood.2024027583. doi: 10.1182/blood.2024027583. Epub ahead of print. PMID: 40504998.
10.06.25
Amini W, Schemmelmann L, Heming JN, Oguama M, Thomas K, Block H, Lindental P, Bardel B, Margraf A, Soehnlein O, Cappenberg A, Zarbock A. Csk-mediated Src family kinase regulation dampens neutrophil infiltration during pulmonary infection. JCI Insight. 2025 Jun 10:e188323. doi: 10.1172/jci.insight.188323. Epub ahead of print. PMID: 40493407.
24.05.25
Thomas K, Rossaint J, Ludwig N, Mersmann S, Kötting N, Grenzheuser J, Schemmelmann L, Oguama M, Margraf A, Block H, Henke K, Hellenthal K, Mirakaj V, Gerke V, Hansen U, Gäher K, Engelhardt M, Roth J, Eble J, Hub E, Rot A, Alon R, Zarbock A. Alveolar epithelial and vascular CXCR2 mediates transcytosis of CXCL1 in inflamed lungs. Nat Commun. 2025 May 24;16(1):4846. doi: 10.1038/s41467-025-60174-w. PMID: 40413164; PMCID: PMC12103508.
23.05.25
Hunkemöller A, Wirth T, Rovas A, Pavenstädt H, Klotz L, Kümpers P. Changes in immune cell signatures during early infection reflect decoupling of capillary perfusion and glycocalyx dimensions. Front Immunol. 2025 May 23;16:1589959. doi: 10.3389/fimmu.2025.1589959. PMID: 40486505; PMCID: PMC12140986.
15.05.25
Honig N, Teubert C, Lamparter L, Keller MN, Austermann J, Berger P, Schmitz A, Rasch C, Nüsse H, Klingauf J, Erpenbeck L, Roth J, Galic M. Primary human neutrophils and monocytes migrate along endothelial cell boundaries to optimize search efficiency under static in vitro conditions. Biol Open. 2025 May 15;14(5):bio061704. doi: 10.1242/bio.061704. Epub 2025 May 13. PMID: 40357751.
29.11.24
Schughart K, Möller-Kerutt A, Höffken V, Nedvetsky P, Groh AC, Braun DA, Pavenstädt H, Weide T. PALS1-dependent modulations of mRNA profiles in MDCK II cells grown in non-confluent monolayers and three-dimensional cysts. BMC Genom Data. 2024 Nov 29;25(1):102. doi: 10.1186/s12863-024-01284-0. PMID: 39614182; PMCID: PMC11607895.
18.09.24
12.08.24
29.01.24
Meersch M, Weiss R, Strauß C, Albert F, Booke H, Forni L, Pittet JF, Kellum JA, Rosner M, Mehta R, Bellomo R, Rosenberger P, Zarbock A; EPIS-AKI Investigators. Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial. Intensive Care Med. 2024 Feb;50(2):247-257
29.11.23
Goretzko J, Pauels I, Heitzig N, Thomas K, Kardell M, Naß J, Krogsaeter EK, Schloer S, Spix B, Linard Matos AL, Leser C, Wegner T, Glorius F, Bracher F, Gerke V, Rossaint J, Grimm C, Rescher U. P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2. Cell Rep. 2023 Nov 29;42(12):113501.
30.10.23
Pruenster M, Immler R, Roth J, Kuchler T, Bromberger T, Napoli M, Nussbaumer K, Rohwedder I, Wackerbarth LM, Piantoni C, Hennis K, Fink D, Kallabis S, Schroll T, Masgrau-Alsina S, Budke A, Liu W, Vestweber D, Wahl-Schott C, Roth J, Meissner F, Moser M, Vogl T, Hornung V, Broz P, Sperandio M. E-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/S100A9 release from neutrophils via transient gasdermin D pore formation. Nat Immunol. 2023 Dec;24(12):2021-2031. Epub 2023 Oct 30.
13.08.23
Rovas A, Neumann JK, Drost CC, Vollenberg R, Thölking G, Fobker M, Witzenrath M, Kümpers P, Agamotto Study Group, Capnetz Study Group. Analysis of Urinary Glycosaminoglycans to Predict Outcome in COVID-19 and Community-Acquired Pneumonia-A Proof-of-Concept Study. J Clin Med. 2023 Aug 13;12(16):5269.
28.07.23
Zarbock A, Weiss R, Albert F, Rutledge K, Kellum JA, Bellomo R, Grigoryev E, Candela-Toha AM, Demir ZA, Legros V, Rosenberger P, Galán Menéndez P, Garcia Alvarez M, Peng K, Léger M, Khalel W, Orhan-Sungur M, Meersch M; The EPIS-AKI Investigators. Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study. Intensive Care Med. 2023 Jul 28. doi: 10.1007/s00134-023-07169-7. Epub ahead of print.
13.07.23
Kleinehr J, Schöfbänker M, Daniel K, Günl F, Mohamed FF, Janowski J, Brunotte L, Boergeling Y, Liebmann M, Behrens M, Gerdemann A, Klotz L, Esselen M, Humpf HU, Ludwig S, Hrincius ER. Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA. PLoS Pathog. 2023 Jul 13;19(7):e1010986. doi: 10.1371/journal.ppat.1010986.
05.04.23
Vöing K, Michgehl U, Mertens ND, Picciotto C, Maywald ML, Goretzko J, Waimann S, Gilhaus K, Rogg M, Schell C, Klingauf J, Tsytsyura Y, Hansen U, van Marck V, Edinger AL, Vollenbröker B, Rescher U, Braun DA, George B, Weide T, Pavenstädt H. Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy. J Am Soc Nephrol. 2023 Apr 5. doi: 10.1681/ASN.0000000000000126.
29.03.23
Meersch M, Weiss R, Gerss J, Albert F, Gruber J, Kellum JA, Chawla L, Forni LG, Koyner JL, von Groote T, Zarbock A. Predicting the Development of Renal Replacement Therapy Indications by Combining the Furosemide Stress Test and Chemokine (C-C Motif) Ligand 14 in a Cohort of Postsurgical Patients. Crit Care Med. 2023 Mar 29. doi: 10.1097/CCM.0000000000005849.
28.03.23
Weiss R, von Groote T, Ostermann M, Lumlertgul N, Weerapolchai K, Garcia MIM, Cano JMM, Del Corral BD, Broch-Porcar MJ, Perez Carrasco M, De la Vega Sanchez A, Sousa E, Catarino A, Roig AJB, Martinez de Irujo JB, de Rosa S, de la Peña MG, Tomasa T, Brivio M, De Molina FJG, Gerss J, Kellum JA, Wempe C, Leidereiter A, Meersch M, Zarbock A. The Role of Cell Cycle Arrest Biomarkers for Predicting Acute Kidney Injury in Critically Ill COVID-19 Patients: A Multicenter, Observational Study. Crit Care Med. 2023 Mar 28. doi: 10.1097/CCM.0000000000005853.
27.03.23
von Groote T, Meersch M, Romagnoli S, Ostermann M, Ripollés-Melchor J, Schneider AG, Vandenberghe W, Monard C, De Rosa S, Cattin L, Rahmel T, Adamzik M, Parise D, Candela-Toha A, Haaker JG, Göbel U, Bernard A, Lumlertgul N, Fernández-Valdes-Bango P, Romero Bhathal I, Suarez-de-la-Rica A, Larmann J, Villa G, Spadaro S, Wulf H, Arndt C, Putensen C, García-Álvarez R, Brandenburger T, Siniscalchi A, Ellerkmann R, Espeter F, Porschen C, Sadjadi M, Saadat-Gilani K, Weiss R, Gerss J, Kellum J, Zarbock A; BigpAK-2 Investigators. Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial. BMJ Open. 2023 Mar 27;13(3):e070240. doi: 10.1136/bmjopen-2022-070240.
13.03.23
de Melo BMS, Veras FP, Zwicky P, Lima D, Ingelfinger F, Varela T, da Silva Prado D, Schärli S, Publio G, Hiroki CH, Melo PH, Saraiva A, Norbiato T, Lima L, Ryffel B, Vogl T, Roth J, Waisman A, Nakaya HI, da Silva Souza C, Cunha FQ, Cunha TM, Becher B, Alves-Filho JC. S100A9 drives the chronification of psoriasiform inflammation by inducing IL-23/type 3 immunity. J Invest Dermatol. 2023 Mar 13:S0022-202X(23)01825-0. doi: 10.1016/j.jid.2023.02.026.
13.03.23
Lin C, Garcia-Gerique L, Bonner EE, Mastio J, Rosenwasser M, Cruz Z, Lawler M, Bernabei L, Muthumani K, Liu Q, Poncz M, Vogl T, Törngren M, Eriksson H, Vogl DT, Gabrilovich DI, Nefedova Y. S100A8/S100A9 Promote Progression of Multiple Myeloma via Expansion of Megakaryocytes. Cancer Res Commun. 2023 Mar 13;3(3):420-430. doi: 10.1158/2767-9764.CRC-22-0368.
23.02.23
Zarbock A, Nadim MK, Pickkers P, Gomez H, Bell S, Joannidis M, Kashani K, Koyner JL, Pannu N, Meersch M, Reis T, Rimmelé T, Bagshaw SM, Bellomo R, Cantaluppi V, Deep A, De Rosa S, Perez-Fernandez X, Husain-Syed F, Kane-Gill SL, Kelly Y, Mehta RL, Murray PT, Ostermann M, Prowle J, Ricci Z, See EJ, Schneider A, Soranno DE, Tolwani A, Villa G, Ronco C, Forni LG. Sepsis-associated acute kidney injury: consensus report of the 28th Acute Diseases Quality Initiative workgroup. Nat Rev Nephrol. 2023 Feb 23. doi: 10.1038/s41581-023-00683-3.
21.02.23
Jorch SK, McNally A, Berger P, Wolf J, Kaiser K, Chetrusca Covash A, Robeck S, Pastau I, Fehler O, Jauch-Speer SL, Hermann S, Schäfers M, Van Gorp H, Kanneganti A, Dehoorne J, Haerynck F, Penco F, Gattorno M, Chae JJ, Kubes P, Lamkanfi M, Wullaert A, Sperandio M, Vogl T, Roth J, Austermann J. Complex regulation of alarmins S100A8/A9 and secretion via Gasdermin-D pores exacerbates autoinflammation in Familial Mediterranean Fever. J Allergy Clin Immunol. 2023 Feb 21:S0091-6749(23)00225-7. doi: 10.1016/j.jaci.2023.01.037.
18.02.23
Haeberle H, Calov S, Martus P, Serna-Higuita LM, Koeppen M, Goll A, Bernard A, Zarbock A, Meersch M, Weiss R, Mehrländer M, Marx G, Putensen C, Bakchoul T, Maguina H, Nieswandt B, Mirakaj V, Rosenberger P. Inhaled prostacyclin therapy in the acute respiratory distress syndrome: a randomized controlled multicenter trial. Respir Res. 2023 Feb 18;24(1):58. doi: 10.1186/s12931-023-02346-0.
13.02.23
Limmer A, Engler A, Kattner S, Gregorius J, Pattberg KT, Schulz R, Schwab J, Roth J, Vogl T, Krawczyk A, Witzke O, Zelinskyy G, Dittmer U, Brenner T, Berger MM. Patients with SARS-CoV-2-Induced Viral Sepsis Simultaneously Show Immune Activation, Impaired Immune Function and a Procoagulatory Disease State. Vaccines (Basel). 2023 Feb 13;11(2):435. doi: 10.3390/vaccines11020435.
11.02.23
Günl F, Krischuns T, Schreiber JA, Henschel L, Wahrenburg M, Drexler HCA, Leidel SA, Cojocaru V, Seebohm G, Mellmann A, Schwemmle M, Ludwig S, Brunotte L. The ubiquitination landscape of the influenza A virus polymerase. Nat Commun. 2023 Feb 11;14(1):787. doi: 10.1038/s41467-023-36389-0. PMID: 36774438; PMCID: PMC9922279.
10.02.23
Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H. Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. Science. 2023 Feb 10;379(6632):586-591. doi: 10.1126/science.add0875.
08.12.22
Regier M, Drost CD, Rauen M, Pavenstädt H, Rovas A, Kümpers P, Vink H, Long RM, Linke WA, Nofer JR, Lukasz AH. A dietary supplement containing fucoidan preserves endothelial glycocalyx through ERK/MAPK signaling and protects against damage induced by CKD serum. Int J Mol Sci. 2022, 23, 15520. doi: 10.3390/ijms232415520.
07.12.22
Jin Y, Ding Y, Richards M, Kaakinen M, Giese W, Baumann E, Szymborska A, Rosa A, Nordling S, Schimmel L, Akmeriç EB, Pena A, Nwadozi E, Jamalpour M, Holstein K, Sáinz-Jaspeado M, Bernabeu MO, Welsh M, Gordon E, Franco CA, Vestweber D, Eklund L, Gerhardt H, Claesson-Welsh L. Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis. Nat Cardiovasc Res. 2022 Dec 7;1(12):1156-1173. doi: 10.1038/s44161-022-00172-z.
06.12.22
He S, Zambelli VO, Sinharoy P, Brabenec L, Bian Y, Rwere F, Hell RC, Stein Neto B, Hung B, Yu X, Zhao M, Luo Z, Wu C, Xu L, Svensson KJ, McAllister SL, Stary CM, Wagner NM, Zhang Y, Gross ER. A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents. J Clin Invest. 2022 Dec 6:e163735. doi:10.1172/JCI163735.
21.11.22
Faist A, Schloer S, Mecate-Zambrano A, Janowski J, […], Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L. 2022. Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier. Antiviral Res 105475. 2022/11/25, 10.1016/j.antiviral.2022.105475.
31.10.22
von Groote T, Albert F, Meersch M, Koch R, Porschen C, Hartmann O, Bergmann D, Pickkers P, Zarbock A. Proenkephalin A 119-159 predicts early and successful liberation from renal replacement therapy in critically ill patients with acute kidney injury: a post hoc analysis of the ELAIN trial. Crit Care. 2022 Oct 31;26(1):333. doi: 10.1186/s13054-022-04217-4.
30.10.22
Russo A, Schürmann H, Brandt M, Scholz K, Matos AL, Grill D, Revenstorff J, Rembrink M, […] Hermann S, Klotz L, Gerke V, Betz T, Vogl T, Roth J. Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes. Adv Sci (Weinh). 2022 Oct 30;e2201505. doi: 10.1002/advs.202201505. Epub ahead of print.
14.10.22
Schenz J, Rump K, Hermann Siegler B, […] von Groote T, Zarbock A, Fiedler MO, Zemva J, Larmann J, Merle U, Adamzik M, Müller-Tidow C, Haferlach T, Leuschner F, Weigand MA. Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19. Front Immunol. 2022 Oct 14;13:968778. doi:10.3389/fimmu.2022.968778. eCollection 2022.
15.09.22
Thomas K, Zondler L, Ludwig N, Kardell M, Lüneburg C, Henke K, Mersmann S, Margraf A, […] Meersch M, Vestweber D, Westphal M, Roth J, Schaefers MA, Kellum JA, Lowell CA, Rossaint J, Zarbock A. Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells. JCI Insight. 2022 Sep 15;e163161. doi: 10.1172/jci.insight.163161. Epub ahead of print.
24.08.22
Schloer S, Treuherz D, Faist A, de Witt M, Wunderlich K, Wiewrodt R, Wiebe K, Barth P, Wälzlein JH, Kummer S, Balkema-Buschmann A, Ludwig S, Brunotte L, Rescher U. 3D ex vivo tissue platforms to investigate the early phases of influenza A virus- and SARS-CoV-2-induced respiratory diseases. Emerg Microbes Infect. 2022 Aug 24;1-30. doi: 10.1080/22221751.2022.2117101. Epub ahead of print.
08.07.22
06.07.22
Aulin C, Larsson S, Vogl T, Roth J, Åkesson A, Swärd P, Heinbäck R, Erlandsson Harris H, Struglics A. The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury. Osteoarthritis Cartilage. 2022 Jul 6;S1063-4584(22)00773-7. doi: 10.1016/j.joca.2022.06.009. Epub ahead of print.
29.06.22
Mildner K, Breitsprecher L, Currie SM, Stegmeyer RI, Stasch M, Volkery S, Psathaki OE, Vestweber D, Zeuschner D. Landmark-based retrieval of inflamed skin vessels enabled by 3D correlative intravital light and volume electron microscopy. Histochem Cell Biol. 2022 Jun 29. doi: 10.1007/s00418-022-02119-8. Epub ahead of print.
21.06.22
Rossaint J, Meersch M, Thomas K, Mersmann S, Lehmann M, Skupski J, Tekath T, Rosenberger P, Kellum JA, Pavenstädt H, Zarbock A. Remote ischemic preconditioning causes transient cell-cycle arrest and renal protection by a NF-kB-dependent Sema5B pathway. JCI Insight. 2022 Jun 21;e158523. doi: 10.1172/jci.insight.158523. Online ahead of print.
21.06.22
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, […], Ludwig S, Suttorp N, Witzenrath M, Gruber AG, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC. Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages. Eur Respir J. 2022 Jun 21;2102725. doi:10.1183/13993003.02725-2021. Epub ahead of print.
20.06.22
Rovas A, Buscher K, Osiaevi I, Drost CC, Sackarnd J, Tepasse PR, Fobker M, Kühn J, Braune S, Göbel U, Thölking G, Gröschel A, Rossaint J, Vink H, Lukasz A, Pavenstädt H, Kümpers P. Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study. Angiogenesis. 2022 Jun 20;1-13. doi: 10.1007/s10456-022-09843-8. Epub ahead of print.
14.06.22
Brabenec L, Müller M, Hellenthal KE, Karsten OS, Pryvalov H, Otto M, Holthenrich A, Linard Matos AL, Weiss R, Kintrup S, Hessler M, Dell’Aquila A, Thomas K, Naß J, Margraf A, Nottebaum AF, Rossaint J, Zarbock A, Vestweber D, Gerke V, Wagner NM. Targeting Procalcitonin Protects Vascular Barrier Integrity. Am J Respir Crit Care Med. 2022 Jun 14.doi: 10.1164/rccm.202201-0054OC. Epub ahead of print.
10.06.22
Drost CC, Rovas A, Osiaevi I, Rauen M, van der Vlag J, Buijsers B, Salmenov R, Lukasz A, Pavenstädt H, Linke WA, Kümpers P. Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study. Front Immunol. 2022 Jun 10;13:916512. doi: 10.3389/fimmu.2022.916512. eCollection 2022.
04.06.22
Meersch M, Weiss R, Küllmar M, Bergmann L, Thompson A, Griep L, Kusmierz D, Buchholz A, Wolf A, Nowak H, Rahmel T, Adamzik M, […], Gerß J, Sessler DI, Wempe C, Massoth C, Zarbock A. Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications Among Adults: The HandiCAP Randomized Clinical Trial. JAMA. 2022 Jun 4. doi: 10.1001/jama.2022.9451. Epub ahead of print.
13.05.22
Gerss J, Meersch M, Kindgen-Milles D, Brandenburger T, Willam C, Kellum JA, Zarbock A, RICH investigators. The Effect of Filter Lifespan during Continuous Renal Replacement Therapy in Critically Ill Patients with AKI on the Rate of New Onset Infection: Analysis from the RICH Randomized Controlled Trial. Am J Respir Crit Care Med. 2022 May 13. doi: 10.1164/rccm.202201-0063LE. Epub ahead of print.
11.05.22
Jauch-Speer SL, Herrera-Rivero M, Ludwig N, Véras De Carvalho BC, Martens L, Wolf J, Chasan AI, Witten A, Markus B, Schieffer B, Vogl T, Rossaint J, Stoll M, Roth J, Fehler O. C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9. Elife. 2022 May 11;11:e75594. doi: 10.7554/eLife.75594. Epub ahead of print.
21.04.22
Li Z, Ludwig N, Thomas K, Mersmann S, Lehmann M, Vestweber D, Pittet JF, Gomez H, Kellum JA, Rossaint J, Zarbock, A. The Pathogenesis of Ischemia-Reperfusion Induced Acute Kidney Injury Depends on Renal Neutrophil Recruitment Whereas Sepsis-Induced AKI Does Not. Front Immunol. 2022 Apr 21;13:843782. doi: 10.3389/fimmu.2022.843782. eCollection 2022.
31.03.22
Currie SM, Stegmeyer R, Mildner K, Breitsprecher L, Zeuschner D, Psathaki OE, Schäfer K, Wilkens M, Volkery S, Nieswandt B, Vestweber D. Confocal Real-Time Analysis of Cutaneous Platelet Recruitment during Immune-Complex-Mediated Inflammation. J Invest Dermatol. 2022 Mar 31;S0022-202X(22)00254-8. doi: 10.1016/j.jid.2022.03.011. Epub ahead of print.
08.03.22
Menuchin-Lasowski Y, Schreiber A, Lecanda A, Mecate-Zambrano A, Brunotte L, Psathaki OE, Ludwig S, Rauen T, Schöler HR. SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids. Stem Cell Reports. 2022 Mar 8; S2213-6711(22)00104-7.doi: 10.1016/j.stemcr.2022.02.015. Epub ahead of print.
22.02.22
Schuhenn J, Meister TL, […] Brunotte L, […] Ludwig S, Sitek B, Steinmann E, Dittmer U, Lavender KJ, Sutter K, Pfaender S. Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection. Proc Natl Acad Sci U S A,. 2022 Feb 22;119(8):e2111600119. doi: 10.1073/pnas.2111600119.
16.02.22
08.02.22
Conrad C, Yildiz D, Cleary SJ, Margraf A, […],Eltzschig HK, CAPSys Study Group; Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight. 2022 Feb 8;7(3):e149870. doi: 10.1172/jci.insight.149870.
10.01.22
Schreiber A, […] Brunotte L, Faist A, Schöfbänker M, Hrincius E, Hoffmann H, Hoffmann M, Pöhlmann S, Rescher U, Planz O, Ludwig S, The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses. Cell Mol Life Sci. 2022 Jan 10;79(1):65.doi: 10.1007/s00018-021-04085-1.
22.10.21
Kruisbergen NNL, Ceglie ID, van Gemert Y, […], Roth J, Vogl T, van der Kraan PM, Blom AB, van Lent PLM, van den Bosch MHJ, Nox 2 Deficiency Reduces Cartilage Damage and Ectopic Bone Formation in an Experimental Model for Osteoarthritis. Antioxidants (Basel). 2021 Oct 22;10(11):1660. doi: 10.3390/antiox10111660.
07.09.21
Nacken W, Schreiber A, Masemann D, Ludwig S, The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus. mBio. 2021 Sep 7;e0219621. doi: 10.1128/mBio.02196-21. Epub ahead of print
01.09.21
Otto M, Brabenec L, Müller M, Kintrup S, Hellenthal KEM, Holtmeier R, Steinbuch SC, Karsten OS, Pryvalov H, Rossaint J, Gross ER, Wagner NM, Development of heart failure with preserved ejection fraction in type 2 diabetic mice is ameliorated by preserving vascular function. Life Sci. 2021 Sep 1;119925. doi: 10.1016/j.lfs.2021.119925. Epub ahead of print.
02.06.21
Buscher K, Heitplatz B, van Marck V, Song J, Loismann S, Rixen R, Hüchtmann B, Kurian S, Ehinger E, Wolf D, Ley K, Pavenstädt H, Reuter S. Data-Driven Kidney Transplant Phenotyping as a Histology-Independent Framework for Biomarker Discovery. J Am Soc Nephrol. 2021 Aug;32(8):1933-1945. doi: 10.1681/ASN.2020121685. Epub 2021 Jun 2.
20.05.21
Rossaint J, Thomas K, Mersmann S, Skupski J, Margraf A, Tekath T, Jouvene CC, Dalli J, Hidalgo A, Meuth SG, Soehnlein O, Zarbock A, Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education. J Exp Med. 2021 Jul 5;218(7):e20201353. doi: 10.1084/jem.20201353. Epub ahead of print.
01.05.21
Küllmar M, Saadat-Gilani K, Weiss R, Massoth C, Lagan A, Cortés MN, Gerss J, Chawla LS, Fliser D, Meersch M, Zarbock A. Kinetic Changes of Plasma Renin Concentrations Predict Acute Kidney Injury in Cardiac Surgery Patients. Am J Respir Crit Care Med. 2021 May 1;203(9):1119-1126. doi: 10.1164/rccm.202005-2050OC.
11.03.21
Bertoglio F, Meier D, […], Brunotte L, Ludwig S, Fühner V, Krämer ST, Dübel S, Varani L, Roth G, Čičin-Šain L, Schubert M, Hust M. SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface. Nat. Commun. 2021 Mar 11;12(1):1577. doi: 10.1038/s41467-021-21609-2.
10.03.21
Massoth C, Küllmar M, Enders D, Kellum JA, Forni LG, Meersch M, Zarbock A, Progressive AKI Group, Comparison of C-C motif chemokine ligand 14 with other biomarkers for adverse kidney events after cardiac surgery. J Thorac Cardiovasc Surg. 2021 Mar 10;S0022-5223(21)00436-0. doi: 10.1016/j.jtcvs.2021.03.016. ePub ahead of print.
09.12.20
Schloer S, Brunotte L, Goretzko J , Mecate-Zambrano A, Korthals N, Gerke V, Ludwig S, Rescher U, Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine. Emerg Microbes Infect. 2020 Dec;9(1):2245-2255. doi: 10.1080/22221751.2020.1829082.
23.10.20
Zarbock A, Küllmar M, Kindgen-Milles D […] Bagshaw SM, Kellum JA, Meersch M. Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial. JAMA. 2020
28.09.20
Schloer S, Brunotte L, Goretzko J, Mecate-Zambrano A, Korthals N, Gerke V, Ludwig S, Rescher U. Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine. Emerg. Microbes Infect. 2020, 9(1): 2245-2255.
01.08.20
Meersch M, Küllmar M, Pavenstädt H, Rossaint J, Kellum JA, Martens S, Klausmeyer P, Schmidt EA, Kerschke L, Zarbock A, Effects of Different Doses of Remote Ischemic Preconditioning on Kidney Damage Among Patients Undergoing Cardiac Surgery: A Single-Center Mechanistic Randomized Controlled Trial. Crit Care Med. 2020 Aug;48(8):e690-e697.
12.07.20
Margraf A, Germena G, Drexler H, Rossaint J, Ludwig N, Prystaj B, Mersmann S, Thomas K, Block H, Gottschlich W, Liu C, Krenn P, Haller H, Heitplatz B, Meyer zu Brickwedde M, Moser M, Vestweber D, Zarbock A. The integrin linked kinase is required for chemokine-triggered high affinity conformation of neutrophil ß2-integrin LFA1. Blood. 2020, 136(19):2200-2205.
08.06.20
Meersch M, Küllmar M, Pavenstädt H, Rossaint J, Kellum JA, Martens S, Klausmeyer P, Schmidt EA, Kerschke L, Zarbock A. Effects of different doses of remote ischemic preconditioning on kidney damage among patients undergoing cardiac surgery – a single-center mechanistic randomized controlled trial. Critical Care Medicine. 2020 Aug;48(8):e690-e697.
12.12.19
Duong CN, Nottebaum AF, Butz S, Volkery S, Zeuschner D, Stehling M, Vestweber D. Interference With ESAM (Endothelial Cell-Selective Adhesion Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate Lethality and Lung-Specific Blood Coagulation. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):378-393.