Hier sind alle Publikationen der Klinischen Forschungsgruppe KFO342 zu finden. Die Publikationsliste wird in umgekehrt chronologischer Reihung geführt.

kfo342 research unit



Zarbock A, The Journey Begins: Personalized Acute Kidney Injury Therapy. Crit Care Med. 2021 Oct 1;49(10):1822-1825. doi: 10.1097/CCM.0000000000005100. Epub ahead of print


Günl F, Mecate-Zambrano A, Rehländer S, Hinse S, Ludwig S, Brunotte L, Shooting at a Moving Target—Effectiveness and Emerging Challenges for SARS-CoV-2 Vaccine Development. Vaccines 2021, 9(10), 1052. Epub ahead of print


Saadat-Gilani K, Zarbock A, Perioperative renal protection. Curr Opin Crit Care. 2021 Sep 15. doi: 10.1097/MCC.0000000000000881.


Nacken W, Schreiber A, Masemann D, Ludwig S, The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus. mBio. 2021 Sep 7;e0219621. doi: 10.1128/mBio.02196-21. Epub ahead of print


Brunotte L, Zheng S, Mecate-Zambrano A, Tang J, Ludwig S, Rescher U, Schloer S, Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro. Pharmaceutics 2021, 13(9), 1400. Epub ahead of print.


Otto M, Brabenec L, Müller M, Kintrup S, Hellenthal KEM, Holtmeier R, Steinbuch SC, Karsten OS, Pryvalov H, Rossaint J, Gross ER, Wagner NM, Development of heart failure with preserved ejection fraction in type 2 diabetic mice is ameliorated by preserving vascular function. Life Sci. 2021 Sep 1;119925. doi: 10.1016/j.lfs.2021.119925. Epub ahead of print.


Kellum JA, Romagnani P, Ashuntantang G, Ronco C, Zarbock A, Anders HJ, Acute kidney injury. Nat Rev Dis Primers. 2021 Jul 15;7(1):52. doi: 10.1038/s41572-021-00284-z.


Boergeling Y, Brunotte L, Ludwig S, Dynamic phospho-modification of viral proteins as a crucial regulatory layer of influenza A virus replication and innate immune responses. Biol Chem. 2021 Jun 1. doi: 10.1515/hsz-2021-0241. Epub ahead of print.


Ackermann M, Anders HJ, […], Zarbock A, Schett G, Herrmann M, Patients with COVID-19: in the dark-NETs of neutrophils. Cell Death Differ. 2021 May 24;1-15. doi: 10.1038/s41418-021-00805-z. Epub ahead of print.


Rossaint J, Thomas K, Mersmann S, Skupski J, Margraf A, Tekath T, Jouvene CC, Dalli J, Hidalgo A, Meuth SG, Soehnlein O, Zarbock A, Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education. J Exp Med. 2021 Jul 5;218(7):e20201353. doi: 10.1084/jem.20201353. Epub ahead of print.


Ninchoji T, Love DT, Smith RO, Hedlund M, Vestweber D, Sessa WC, Welsh LC, eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin. Elife. 2021 Apr 28;10:e64944. doi: 10.7554/eLife.64944.


Pirr S, Dauter L, Vogl T, Ulas T, Bohnhorst B, Roth J, Viemann D, S100A8/A9 is the first predictive marker for neonatal sepsis. Clin Transl Med. 2021 Apr;11(4):e338. doi: 10.1002/ctm2.338.


Rovas A, Sackarnd J, Rossaint J, Kampmeier S, Pavenstädt H, Vink H, Kümpers P. Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study. Crit Care. 2021 Mar 19;25(1):112. doi: 10.1186/s13054-021-03520-w.


Bertoglio F, Meier D, […], Brunotte L, Ludwig S, Fühner V, Krämer ST, Dübel S, Varani L, Roth G, Čičin-Šain L, Schubert M, Hust M. SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface. Nat. Commun. 2021 Mar 11;12(1):1577. doi: 10.1038/s41467-021-21609-2.


Massoth C, Küllmar M, Enders D, Kellum JA, Forni LG, Meersch M, Zarbock A, Progressive AKI Group, Comparison of C-C motif chemokine ligand 14 with other biomarkers for adverse kidney events after cardiac surgery. J Thorac Cardiovasc Surg. 2021 Mar 10;S0022-5223(21)00436-0. doi: 10.1016/j.jtcvs.2021.03.016. ePub ahead of print.


Tran GVQ, Kleinehr J, Preugschas HF, Anhlan D, Mohamed FF, Ehrhardt C, Ludwig S, Hrincius ER, Nonsense-mediated mRNA decay does not restrict influenza A virus propagation. Cell Microbiol. 2021 Mar 2. doi: 10.1111/cmi.13323. ePub ahead of print


Schwierzeck V König JC, Kühn J, Mellmann A, Correa-Martínez CL, Omran H,  Konrad M, Kaiser T, Kampmeier S, First Reported Nosocomial Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 in a Pediatric Dialysis Unit. Clin Infect Dis. 2021 Jan 27;72(2):265-270. doi: 10.1093/cid/ciaa491


Patil A, Anhlan D Ferrando V, Mecate-Zambrano A, Mellmann A, Wixler V, Boergeling Y, Ludwig S, Phosphorylation of influenza A virus NS1 at serine 205 mediates its viral polymerase-enhancing function. J Virol. 2021 Jan 6;JVI.02369-20. ePub ahead of print


Küllmar M, Saadat-Gilani K, Weiss R, Massoth C, Lagan A, Nunez Cortes M, Gerss J, Chawla LS, Fliser D, Meersch M, Zarbock A, Kinetic Changes of Plasma Renin Levels Predict Acute Kidney Injury in Cardiac Surgery Patients. Am J Respir Crit Care Med. 2020, Dec 15. ePub ahead of print


Wilden JJ, Hrincius ER, Niemann S, Boergeling Y, Löffler B, Ludwig S, Ehrhardt C, Impact of Staphylococcus aureus Small Colony Variants on Human Lung Epithelial Cells with Subsequent Influenza Virus Infection. Microorganisms. 2020, 8(12), 1998.


Schloer S, Brunotte L, Goretzko J , Mecate-Zambrano A, Korthals N, Gerke V, Ludwig S, Rescher U, Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine. Emerg Microbes Infect. 2020 Dec;9(1):2245-2255. doi: 10.1080/22221751.2020.1829082.


Masemann D, Ludwig S, Boergeling Y, Advances in Transgenic Mouse Models to Study Infections by Human Pathogenic Viruses. Int. J. Mol. Sci. 2020,21(23) 9289.


Saadat-Gilani K, Zarbock A, Meersch M, Perioperative Renoprotection: Clinical Implications. Anesth Analg. 2020 Dec;131(6):1667-1678.


Alon R, Sportiello M, Kozlovski S, Kumar A, Reilly EC, Zarbock A, Garbi N, Topham DJ, Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19. Nat Rev Immunol. 2020 Nov 19: 1–16. ePub ahead of print


Zarbock A, Küllmar M, Kindgen-Milles D […] Bagshaw SM, Kellum JA, Meersch M. Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial. JAMA. 2020 324(16):1629-1639.


Boff L, Schreiber A, da Rocha Matos A, Del Sarto J, Brunotte L […] Ludwig S. Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation. Molecules. 2020 Oct 21;25(20):E4853


Nadim MK, Forni LG, Mehta RL, Connor MJ Jr, Liu KD, Ostermann M, Rimmelé T, Zarbock A […] Kellum JA. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol. 2020, 16: 747-764.


Rovas A, Osiaevi I, Buscher K, Sackarnd J, Tepasse PR, Fobker M, Kühn J, Braune S, Göbel U, Thölking G, Gröschel A, Pavenstädt H, Vink H, Kümpers P. Microvascular dysfunction in COVID-19: the MYSTIC study. Angiogenesis. 2020 Oct 14:1-13. ePub ahead of print


Kane-Gill SL, Meersch M, Bell M. Biomarker-guided management of acute kidney injury. Curr Opin Crit Care. 2020, 26(6):556-562.


Ostermann M, Zarbock A, Goldstein S […] Shaw AD, Kellum JA, Ronco C. Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference: A Consensus Statement. JAMA Netw Open. 2020 Oct 1;3(10)e2019209.


Schloer S, Brunotte L, Goretzko J, Mecate-Zambrano A, Korthals N, Gerke V, Ludwig S, Rescher U. Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine. Emerg. Microbes Infect. 2020, 9(1): 2245-2255.


Meersch M, Zarbock A. Preemptive renal replacement therapy in critically ill patients? Ann. Transl. Med. 2020;8(16):978.


Küllmar M, Zarbock A, Engelmann DT, Chatterjee S, Wagner NM. Prevention of Acute Kidney Injury. Crit. Clin. 2020, 36(4):691-704.


Gerlach M , S Wolff S, Ludwig S, Schäfer W, Keiner B, Roth NJ, Widmer E, Rapid SARS-CoV-2 inactivation by commonly available chemicals on inanimate surfaces. J Hosp Infect. 2020 Nov;106(3):633-634. doi: 10.1016/j.jhin.2020.09.001. Epub 2020 Sep 9.



Meersch M, Küllmar M, Pavenstädt H, Rossaint J, Kellum JA, Martens S, Klausmeyer P, Schmidt EA, Kerschke L, Zarbock A, Effects of Different Doses of Remote Ischemic Preconditioning on Kidney Damage Among Patients Undergoing Cardiac Surgery: A Single-Center Mechanistic Randomized Controlled Trial. Crit Care Med. 2020 Aug;48(8):e690-e697.


Schreiber A, Boff L, Anhlan D, Krischuns T, Brunotte L, Schuberth C, Wedlich-Söldner R, Drexler H, Ludwig S. Dissecting the mechanisms of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes. PNAS. 2020 July 14;117(28):16557-16566.


Margraf A, Germena G, Drexler H, Rossaint J, Ludwig N, Prystaj B, Mersmann S, Thomas K, Block H, Gottschlich W, Liu C, Krenn P, Haller H, Heitplatz B, Meyer zu Brickwedde M, Moser M, Vestweber D, Zarbock A. The integrin linked kinase is required for chemokine-triggered high affinity conformation of neutrophil ß2-integrin LFA1. Blood. 2020, 136(19):2200-2205.


Ludwig S, Zarbock A, Coronaviruses and SARS-CoV-2: A Brief Overview. Anesth Analg. 2020 Jul;131(1):93-96. doi: 10.1213/ANE.0000000000004845.


Margraf A, Cappenberg A, Vadillo E, Ludwig N, Thomas K, Körner K, Zondler L, Rossaint J, Germena G, Hirsch E, Zarbock A. ArhGAP15, a RacGAP, acts as a temporal signaling regulator of Mac-1 affinity in sterile inflammation. J Immunol. 2020, 205(5): 1365-1375.


Otto M, Bucher C, Liu W, Müller M, Schmidt T, Kardell M, Driessen MN, Rossaint J, Gross ER, Wager NM. 12(S)-HETE mediates diabetes induced endothelial dysfunction by activating intracellular endothelial cell TRPV1. J Clin Invest. 2020 Sep 1;130(9):4999-5010.


Meersch M, Küllmar M, Pavenstädt H, Rossaint J, Kellum JA, Martens S, Klausmeyer P,  Schmidt EA, Kerschke L, Zarbock A. Effects of different doses of remote ischemic preconditioning on kidney damage among patients undergoing cardiac surgery – a single-center mechanistic randomized controlled trial. Critical Care Medicine. 2020 Aug;48(8):e690-e697.


Kehl A, Kuhn R, Detzner J, Steil D, Müthing J, Karch H, Mellmann A. Modeling native EHEC outer membrane vesicles by creating synthetic surrogates. Microorganisms. 2020 May 6;8(5):E673.


Braun LJ, Stegmeyer R, Schäfer K […] Kempe B, Nottebaum AF, Vestweber D. Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2. Blood. 2020 May 5.


Schwierzeck V, König JC, Kühn J, Mellmann A […] Konrad M, Kaiser T, Kampmeier S. First reported nosocomial outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a pediatric dialysis unit. Clin Infect Dis. 2020 Apr 27.


Laure M, Hamza H, Koch-Heier J […] Pleschka S, Ludwig S, Planz O. Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model. Antiviral Res. 2020 Apr 15;178:104806.


Correa-Martínez CL, Kampmeier S, Kümpers P […] Pavenstädt H, Ludwig S, Mellmann A. A pandemic in times of global tourism: superspreading and exportation of COVID-19 cases from a ski area in Austria. J Clin Microbiol. 2020 Apr 3.


Küllmar M, Weiß R, Ostermann M […] Wempe C, Meersch M, Zarbock A. A Multinational Observational Study Exploring Adherence With the Kidney Disease: Improving Global Outcomes Recommendations for Prevention of Acute Kidney Injury After Cardiac Surgery. Anesth Analg. 2020, 130(4), 910-916.


Ludwig S, Zarbock A. Coronaviruses and SARS-CoV-2: A Brief Overview. Anesth Analg. 2020 Mar;31.


Fischer-Riepe L, Daber N, Schulte-Schrepping J […] Schultze JL, Roth J, Barczyk-Kahlert K. CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow. J Allergy Clin Immunol. 2020 Mar 19. 


Schreiber A, Liedmann S, Brunotte L, Anhlan D, Ehrhardt C, Ludwig S. Type I interferon antagonistic properties of influenza B virus polymerase proteins. Cell Microbiol. 2020 Feb;22(2):e13143.


Liu W, Eczko JC, Otto M, Bajorat R, Vollmar B, Roesner JP, Wagner NM. Toll-like receptor 2-deficiency on bone marrow-derived cells augments vascular healing of murine arterial lesions. Life Sci. 2020 Feb 1;242:117189.


Lindemann O, Rossaint J, Najder K, Schimmelpfennig S, Hofschröer V, Wälte M, Fels B, Oberleithner H, Zarbock A, Schwab A. Intravascular adhesion and recruitment of neutrophils in response to CXCL1 depends on their TRPC6 channels. J Mol Med (Berl). 2020 Jan 16.


Duong CN, Nottebaum AF, Butz S, Volkery S, Zeuschner D, Stehling M, Vestweber D. Interference With ESAM (Endothelial Cell-Selective Adhesion Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate Lethality and Lung-Specific Blood Coagulation. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):378-393.


Drost CC, Rovas A, Kusche-Vihrog K, Van Slyke P, Kim H, Hoang VC, Maynes JT, Wennmann DO, Pavenstädt H, Linke W, Lukasz A, Hesse B, Kümpers P. Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis. Thromb Haemost. 2019 Nov;119(11):1827-1838.


Braun LJ, Zinnhardt M, Vockel M, Drexler HC, Peters K, Vestweber D. VE-PTP inhibition stabilizes endothelial junctions by activating FGD5. EMBO Rep. 2019 Jul;20(7):e47046.


Matos ADR, Wunderlich K, Schloer S […] Matera N, Ludwig S, Brunotte L. Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities. Emerg Microbes Infect. 2019;8(1):1763-1776.