Publikationen
Hier sind alle Publikationen der Klinischen Forschungsgruppe KFO342 zu finden. Die Publikationsliste wird in umgekehrt chronologischer Reihung geführt.

Publikationsliste
08.12.22
Regier M, Drost CD, Rauen M, Pavenstädt H, Rovas A, Kümpers P, Vink H, Long RM, Linke WA, Nofer JR, Lukasz AH. A dietary supplement containing fucoidan preserves endothelial glycocalyx through ERK/MAPK signaling and protects against damage induced by CKD serum. Int J Mol Sci. 2022, 23, 15520. doi: 10.3390/ijms232415520.
06.12.22
He S, Zambelli VO, Sinharoy P, Brabenec L, Bian Y, Rwere F, Hell RC, Stein Neto B, Hung B, Yu X, Zhao M, Luo Z, Wu C, Xu L, Svensson KJ, McAllister SL, Stary CM, Wagner NM, Zhang Y, Gross ER. A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents. J Clin Invest. 2022 Dec 6:e163735. doi:10.1172/JCI163735.
21.11.22
Faist A, Schloer S, Mecate-Zambrano A, Janowski J, […], Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L. 2022. Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier. Antiviral Res 105475. 2022/11/25, 10.1016/j.antiviral.2022.105475.
31.10.22
von Groote T, Albert F, Meersch M, Koch R, Porschen C, Hartmann O, Bergmann D, Pickkers P, Zarbock A. Proenkephalin A 119-159 predicts early and successful liberation from renal replacement therapy in critically ill patients with acute kidney injury: a post hoc analysis of the ELAIN trial. Crit Care. 2022 Oct 31;26(1):333. doi: 10.1186/s13054-022-04217-4.
30.10.22
Russo A, Schürmann H, Brandt M, Scholz K, Matos AL, Grill D, Revenstorff J, Rembrink M, […] Hermann S, Klotz L, Gerke V, Betz T, Vogl T, Roth J. Alarming and Calming: Opposing Roles of S100A8/S100A9 Dimers and Tetramers on Monocytes. Adv Sci (Weinh). 2022 Oct 30;e2201505. doi: 10.1002/advs.202201505. Epub ahead of print.
14.10.22
Schenz J, Rump K, Hermann Siegler B, […] von Groote T, Zarbock A, Fiedler MO, Zemva J, Larmann J, Merle U, Adamzik M, Müller-Tidow C, Haferlach T, Leuschner F, Weigand MA. Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19. Front Immunol. 2022 Oct 14;13:968778. doi:10.3389/fimmu.2022.968778. eCollection 2022.
15.09.22
Thomas K, Zondler L, Ludwig N, Kardell M, Lüneburg C, Henke K, Mersmann S, Margraf A, […] Meersch M, Vestweber D, Westphal M, Roth J, Schaefers MA, Kellum JA, Lowell CA, Rossaint J, Zarbock A. Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells. JCI Insight. 2022 Sep 15;e163161. doi: 10.1172/jci.insight.163161. Epub ahead of print.
24.08.22
Schloer S, Treuherz D, Faist A, de Witt M, Wunderlich K, Wiewrodt R, Wiebe K, Barth P, Wälzlein JH, Kummer S, Balkema-Buschmann A, Ludwig S, Brunotte L, Rescher U. 3D ex vivo tissue platforms to investigate the early phases of influenza A virus- and SARS-CoV-2-induced respiratory diseases. Emerg Microbes Infect. 2022 Aug 24;1-30. doi: 10.1080/22221751.2022.2117101. Epub ahead of print.
08.07.22
06.07.22
Aulin C, Larsson S, Vogl T, Roth J, Åkesson A, Swärd P, Heinbäck R, Erlandsson Harris H, Struglics A. The alarmins high mobility group box protein 1 and S100A8/A9 display different inflammatory profiles after acute knee injury. Osteoarthritis Cartilage. 2022 Jul 6;S1063-4584(22)00773-7. doi: 10.1016/j.joca.2022.06.009. Epub ahead of print.
29.06.22
Mildner K, Breitsprecher L, Currie SM, Stegmeyer RI, Stasch M, Volkery S, Psathaki OE, Vestweber D, Zeuschner D. Landmark-based retrieval of inflamed skin vessels enabled by 3D correlative intravital light and volume electron microscopy. Histochem Cell Biol. 2022 Jun 29. doi: 10.1007/s00418-022-02119-8. Epub ahead of print.
21.06.22
Rossaint J, Meersch M, Thomas K, Mersmann S, Lehmann M, Skupski J, Tekath T, Rosenberger P, Kellum JA, Pavenstädt H, Zarbock A. Remote ischemic preconditioning causes transient cell-cycle arrest and renal protection by a NF-kB-dependent Sema5B pathway. JCI Insight. 2022 Jun 21;e158523. doi: 10.1172/jci.insight.158523. Online ahead of print.
21.06.22
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, […], Ludwig S, Suttorp N, Witzenrath M, Gruber AG, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC. Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages. Eur Respir J. 2022 Jun 21;2102725. doi:10.1183/13993003.02725-2021. Epub ahead of print.
20.06.22
Rovas A, Buscher K, Osiaevi I, Drost CC, Sackarnd J, Tepasse PR, Fobker M, Kühn J, Braune S, Göbel U, Thölking G, Gröschel A, Rossaint J, Vink H, Lukasz A, Pavenstädt H, Kümpers P. Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study. Angiogenesis. 2022 Jun 20;1-13. doi: 10.1007/s10456-022-09843-8. Epub ahead of print.
14.06.22
Brabenec L, Müller M, Hellenthal KE, Karsten OS, Pryvalov H, Otto M, Holthenrich A, Linard Matos AL, Weiss R, Kintrup S, Hessler M, Dell’Aquila A, Thomas K, Naß J, Margraf A, Nottebaum AF, Rossaint J, Zarbock A, Vestweber D, Gerke V, Wagner NM. Targeting Procalcitonin Protects Vascular Barrier Integrity. Am J Respir Crit Care Med. 2022 Jun 14.doi: 10.1164/rccm.202201-0054OC. Epub ahead of print.
10.06.22
Drost CC, Rovas A, Osiaevi I, Rauen M, van der Vlag J, Buijsers B, Salmenov R, Lukasz A, Pavenstädt H, Linke WA, Kümpers P. Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study. Front Immunol. 2022 Jun 10;13:916512. doi: 10.3389/fimmu.2022.916512. eCollection 2022.
04.06.22
Meersch M, Weiss R, Küllmar M, Bergmann L, Thompson A, Griep L, Kusmierz D, Buchholz A, Wolf A, Nowak H, Rahmel T, Adamzik M, […], Gerß J, Sessler DI, Wempe C, Massoth C, Zarbock A. Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications Among Adults: The HandiCAP Randomized Clinical Trial. JAMA. 2022 Jun 4. doi: 10.1001/jama.2022.9451. Epub ahead of print.
13.05.22
Gerss J, Meersch M, Kindgen-Milles D, Brandenburger T, Willam C, Kellum JA, Zarbock A, RICH investigators. The Effect of Filter Lifespan during Continuous Renal Replacement Therapy in Critically Ill Patients with AKI on the Rate of New Onset Infection: Analysis from the RICH Randomized Controlled Trial. Am J Respir Crit Care Med. 2022 May 13. doi: 10.1164/rccm.202201-0063LE. Epub ahead of print.
11.05.22
Jauch-Speer SL, Herrera-Rivero M, Ludwig N, Véras De Carvalho BC, Martens L, Wolf J, Chasan AI, Witten A, Markus B, Schieffer B, Vogl T, Rossaint J, Stoll M, Roth J, Fehler O. C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9. Elife. 2022 May 11;11:e75594. doi: 10.7554/eLife.75594. Epub ahead of print.
21.04.22
Li Z, Ludwig N, Thomas K, Mersmann S, Lehmann M, Vestweber D, Pittet JF, Gomez H, Kellum JA, Rossaint J, Zarbock, A. The Pathogenesis of Ischemia-Reperfusion Induced Acute Kidney Injury Depends on Renal Neutrophil Recruitment Whereas Sepsis-Induced AKI Does Not. Front Immunol. 2022 Apr 21;13:843782. doi: 10.3389/fimmu.2022.843782. eCollection 2022.
31.03.22
Currie SM, Stegmeyer R, Mildner K, Breitsprecher L, Zeuschner D, Psathaki OE, Schäfer K, Wilkens M, Volkery S, Nieswandt B, Vestweber D. Confocal Real-Time Analysis of Cutaneous Platelet Recruitment during Immune-Complex-Mediated Inflammation. J Invest Dermatol. 2022 Mar 31;S0022-202X(22)00254-8. doi: 10.1016/j.jid.2022.03.011. Epub ahead of print.
08.03.22
Menuchin-Lasowski Y, Schreiber A, Lecanda A, Mecate-Zambrano A, Brunotte L, Psathaki OE, Ludwig S, Rauen T, Schöler HR. SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids. Stem Cell Reports. 2022 Mar 8; S2213-6711(22)00104-7.doi: 10.1016/j.stemcr.2022.02.015. Epub ahead of print.
22.02.22
Schuhenn J, Meister TL, […] Brunotte L, […] Ludwig S, Sitek B, Steinmann E, Dittmer U, Lavender KJ, Sutter K, Pfaender S. Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection. Proc Natl Acad Sci U S A,. 2022 Feb 22;119(8):e2111600119. doi: 10.1073/pnas.2111600119.
16.02.22
08.02.22
Conrad C, Yildiz D, Cleary SJ, Margraf A, […],Eltzschig HK, CAPSys Study Group; Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight. 2022 Feb 8;7(3):e149870. doi: 10.1172/jci.insight.149870.
10.01.22
Schreiber A, […] Brunotte L, Faist A, Schöfbänker M, Hrincius E, Hoffmann H, Hoffmann M, Pöhlmann S, Rescher U, Planz O, Ludwig S, The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses. Cell Mol Life Sci. 2022 Jan 10;79(1):65.doi: 10.1007/s00018-021-04085-1.
22.10.21
Kruisbergen NNL, Ceglie ID, van Gemert Y, […], Roth J, Vogl T, van der Kraan PM, Blom AB, van Lent PLM, van den Bosch MHJ, Nox 2 Deficiency Reduces Cartilage Damage and Ectopic Bone Formation in an Experimental Model for Osteoarthritis. Antioxidants (Basel). 2021 Oct 22;10(11):1660. doi: 10.3390/antiox10111660.
07.09.21
Nacken W, Schreiber A, Masemann D, Ludwig S, The Effector Domain of the Influenza A Virus Nonstructural Protein NS1 Triggers Host Shutoff by Mediating Inhibition and Global Deregulation of Host Transcription When Associated with Specific Structures in the Nucleus. mBio. 2021 Sep 7;e0219621. doi: 10.1128/mBio.02196-21. Epub ahead of print
01.09.21
Otto M, Brabenec L, Müller M, Kintrup S, Hellenthal KEM, Holtmeier R, Steinbuch SC, Karsten OS, Pryvalov H, Rossaint J, Gross ER, Wagner NM, Development of heart failure with preserved ejection fraction in type 2 diabetic mice is ameliorated by preserving vascular function. Life Sci. 2021 Sep 1;119925. doi: 10.1016/j.lfs.2021.119925. Epub ahead of print.
20.05.21
Rossaint J, Thomas K, Mersmann S, Skupski J, Margraf A, Tekath T, Jouvene CC, Dalli J, Hidalgo A, Meuth SG, Soehnlein O, Zarbock A, Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education. J Exp Med. 2021 Jul 5;218(7):e20201353. doi: 10.1084/jem.20201353. Epub ahead of print.
11.03.21
Bertoglio F, Meier D, […], Brunotte L, Ludwig S, Fühner V, Krämer ST, Dübel S, Varani L, Roth G, Čičin-Šain L, Schubert M, Hust M. SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface. Nat. Commun. 2021 Mar 11;12(1):1577. doi: 10.1038/s41467-021-21609-2.
10.03.21
Massoth C, Küllmar M, Enders D, Kellum JA, Forni LG, Meersch M, Zarbock A, Progressive AKI Group, Comparison of C-C motif chemokine ligand 14 with other biomarkers for adverse kidney events after cardiac surgery. J Thorac Cardiovasc Surg. 2021 Mar 10;S0022-5223(21)00436-0. doi: 10.1016/j.jtcvs.2021.03.016. ePub ahead of print.
27.01.21
Schwierzeck V, König JC, Kühn J, Mellmann A, Correa-Martínez CL, Omran H, Konrad M, Kaiser T, Kampmeier S, First Reported Nosocomial Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 in a Pediatric Dialysis Unit. Clin Infect Dis. 2021 Jan 27;72(2):265-270. doi: 10.1093/cid/ciaa491
09.12.20
Schloer S, Brunotte L, Goretzko J , Mecate-Zambrano A, Korthals N, Gerke V, Ludwig S, Rescher U, Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine. Emerg Microbes Infect. 2020 Dec;9(1):2245-2255. doi: 10.1080/22221751.2020.1829082.
23.10.20
Zarbock A, Küllmar M, Kindgen-Milles D […] Bagshaw SM, Kellum JA, Meersch M. Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial. JAMA. 2020 324(16):1629-1639.
28.09.20
Schloer S, Brunotte L, Goretzko J, Mecate-Zambrano A, Korthals N, Gerke V, Ludwig S, Rescher U. Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine. Emerg. Microbes Infect. 2020, 9(1): 2245-2255.
01.08.20
Meersch M, Küllmar M, Pavenstädt H, Rossaint J, Kellum JA, Martens S, Klausmeyer P, Schmidt EA, Kerschke L, Zarbock A, Effects of Different Doses of Remote Ischemic Preconditioning on Kidney Damage Among Patients Undergoing Cardiac Surgery: A Single-Center Mechanistic Randomized Controlled Trial. Crit Care Med. 2020 Aug;48(8):e690-e697.
12.07.20
Margraf A, Germena G, Drexler H, Rossaint J, Ludwig N, Prystaj B, Mersmann S, Thomas K, Block H, Gottschlich W, Liu C, Krenn P, Haller H, Heitplatz B, Meyer zu Brickwedde M, Moser M, Vestweber D, Zarbock A. The integrin linked kinase is required for chemokine-triggered high affinity conformation of neutrophil ß2-integrin LFA1. Blood. 2020, 136(19):2200-2205.
08.06.20
Meersch M, Küllmar M, Pavenstädt H, Rossaint J, Kellum JA, Martens S, Klausmeyer P, Schmidt EA, Kerschke L, Zarbock A. Effects of different doses of remote ischemic preconditioning on kidney damage among patients undergoing cardiac surgery – a single-center mechanistic randomized controlled trial. Critical Care Medicine. 2020 Aug;48(8):e690-e697.
12.12.19
Duong CN, Nottebaum AF, Butz S, Volkery S, Zeuschner D, Stehling M, Vestweber D. Interference With ESAM (Endothelial Cell-Selective Adhesion Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate Lethality and Lung-Specific Blood Coagulation. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):378-393.