Organ Dysfunction during Systemic Inflammation
Clinical Research Unit CRU342 – Bridging Basic Science and Clinical Research
Systemic Inflammation and Organ Dysfunction. Serious clinical problems
The Clinical Research Unit CRU342 will identify and investigate the different pathophysiological mechanisms that contribute to the development of this devastating diseases. We target possible interventional strategies in preclinical disease models and conduct clinical studies to enforce clinical translation of the results and to discover avenues of potential therapeutic approaches to combat organ injury during systemic inflammation.
28.07.23
Zarbock A, Weiss R, Albert F, Rutledge K, Kellum JA, Bellomo R, Grigoryev E, Candela-Toha AM, Demir ZA, Legros V, Rosenberger P, Galán Menéndez P, Garcia Alvarez M, Peng K, Léger M, Khalel W, Orhan-Sungur M, Meersch M; The EPIS-AKI Investigators. Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study. Intensive Care Med. 2023 Jul 28. doi: 10.1007/s00134-023-07169-7. Epub ahead of print.
15.09.22
Thomas K, Zondler L, Ludwig N, Kardell M, Lüneburg C, Henke K, Mersmann S, Margraf A, Spieker T, Tekath T, Velic A, Holtmeier R, Hermann J, Jankowski V, Meersch M, Vestweber D, Westphal M, Roth J, Schaefers MA, Kellum JA, Lowell CA, Rossaint J, Zarbock A. Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells. JCI Insight. 2022 Nov 8;7(21):e163161. doi: 10.1172/jci.insight.163161
04.06.22
Meersch M, Weiss R, Küllmar M, Bergmann L, Thompson A, Griep L, Kusmierz D, Buchholz A, Wolf A, Nowak H, Rahmel T, Adamzik M, […], Gerß J, Sessler DI, Wempe C, Massoth C, Zarbock A. Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications Among Adults: The HandiCAP Randomized Clinical Trial. JAMA. 2022 Jun 4. doi: 10.1001/jama.2022.9451. Epub ahead of print.