Organ Dysfunction during Systemic Inflammation

Clinical Research Unit CRU342 – Bridging Basic Science and Clinical Research

Systemic Inflammation and Organ Dysfunction. Serious clinical problems

The Clinical Research Unit CRU342 will identify and investigate the different pathophysiological mechanisms that contribute to the development of this devastating diseases. We target possible interventional strategies in preclinical disease models and conduct clinical studies to enforce clinical translation of the results and to discover avenues of potential therapeutic approaches to combat organ injury during systemic inflammation.


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Rovas A, Sackarnd J, Rossaint J, Kampmeier S, Pavenstädt H, Vink H, Kümpers P. Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study. Crit Care. 2021 Mar 19;25(1):112. doi: 10.1186/s13054-021-03520-w.


Patil A, Anhlan D Ferrando V, Mecate-Zambrano A, Mellmann A, Wixler V, Boergeling Y, Ludwig S, Phosphorylation of influenza A virus NS1 at serine 205 mediates its viral polymerase-enhancing function. J Virol. 2021 Jan 6;JVI.02369-20. 


Zarbock A, Küllmar M […] Kellum JA, Meersch M. Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial. JAMA. 2020 Oct 23.


Rovas A, Osiaevi I, Buscher K, Sackarnd J, Tepasse PR, Fobker M, Kühn J, Braune S, Göbel U, Thölking G, Gröschel A, Pavenstädt H, Vink H, Kümpers P. Microvascular dysfunction in COVID-19: the MYSTIC study. Angiogenesis. 2020 Oct 14:1-13. ePub ahead of print


Küllmar M, Zarbock A, Engelmann DT, Chatterjee S, Wagner NM. Prevention of Acute Kidney Injury. Crit. Clin. 2020 Oct;36(4):691-704.