Organ Dysfunction during Systemic Inflammation

Clinical Research Unit CRU342 – Bridging Basic Science and Clinical Research

Systemic Inflammation and Organ Dysfunction. Serious clinical problems

The Clinical Research Unit CRU342 will identify and investigate the different pathophysiological mechanisms that contribute to the development of this devastating diseases. We target possible interventional strategies in preclinical disease models and conduct clinical studies to enforce clinical translation of the results and to discover avenues of potential therapeutic approaches to combat organ injury during systemic inflammation.


Meet our research unit

We keep you informed


Drost CC, Rovas A, Osiaevi I, Schughart K, Lukasz A, Linke WA, Pavenstädt H, Kümpers P. Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis. Angiogenesis. 2024 Apr 10. doi: 10.1007/s10456-024-09916-w. Epub ahead of print.


Schreiber A, Rodner F, Oberberg N, Anhlan D, Bletz S, Mellmann A, Planz O, Ludwig S. The host-targeted antiviral drug Zapnometinib exhibits a high barrier to the development of SARS-CoV-2 resistance. Antiviral Res. 2024 May;225:105840. doi:10.1016/j.antiviral.2024.105840. Epub 2024 Mar 2.


Meersch M, Weiss R, Strauß C, Albert F, Booke H, Forni L, Pittet JF, Kellum JA, Rosner M, Mehta R, Bellomo R, Rosenberger P, Zarbock A; EPIS-AKI Investigators. Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial. Intensive Care Med. 2024 Feb;50(2):247-257. doi: 10.1007/s00134-023-07314-2. Epub 2024 Jan 29


Zarbock A, Weiss R, Albert F, Rutledge K, Kellum JA, Bellomo R, Grigoryev E, Candela-Toha AM, Demir ZA, Legros V, Rosenberger P, Galán Menéndez P, Garcia Alvarez M, Peng K, Léger M, Khalel W, Orhan-Sungur M, Meersch M; The EPIS-AKI Investigators. Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study. Intensive Care Med. 2023 Jul 28. doi: 10.1007/s00134-023-07169-7. Epub ahead of print.


Shirakura K, Baluk P, Nottebaum AF, Ipe U, Peters KG, McDonald DM, Vestweber D. Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration. EMBO Mol Med. 2023. Feb 6;e16128. doi: 10.15252/emmm.202216128.


Revenstorff J, Ludwig N, Hilger A, Mersmann S, Lehmann M, Grenzheuser JC, Kardell M, Bone J, Kötting NM, Marx NC, Roth J, Vogl T, Rossaint J. Role of S100A8/A9 in Platelet-Neutrophil Complex Formation during Acute Inflammation. Cells. 2022 Dec 6;11(23):3944. doi: 10.3390/cells11233944.