Bridging Basic Science and Clinical Research

An integral approach

Individual Excellence. Common Success.

The molecular mechanisms of organ damage during systemic inflammation and sepsis are incompletely understood. Importantly, no specific treatment strategy exists to efficiently prevent the development of multi-organ failure during systemic inflammation. The central aim of the KFO342 is the identification and investigation of relevant molecular, immunological and cellular pathways involved in organ dysfunction during systemic inflammation and sepsis, and the identification and investigation of therapeutic treatment strategies.

This will lead to the development of new treatment approaches for patients suffering from systemic inflammatory syndromes and sepsis. The KFO342 comprises projects focusing on different organ systems in the fields of inflammation, cell biology, imaging, microbiology and clinical management of sepsis and organ failure. The KFO342 provides a strong research network combining individual projects investigating different aspects of systemic inflammation and organ dysfunction.

Cooperative Research Network

Immune system dysregulation and endothelial dysfunction are major factors contributing to the deleterious effects of systemic inflammation. We acknowledge this by a comprehensive view on the consequences of this pathological processes on the lung and the kidneys, two of the major organ systems which are most often affected during organ dysfunction following systemic inflammation.  

kfo342-infografik-project2

Endothelium

P1

Procalcitonin as a mediator of sepsis-induced endothelial barrier dysfunction

P2

How VE-PTP and Tie-2 regulate endothelial cell junctions in VE-cadherin dependent and independent ways

Immune System

P3

Myeloid differentiation in systemic inflammation

P4

Characterization of the interaction of bacterial determinants and host cells during systemic inflammation for sepsis prediction

Lung

P5

The role of the alarmin S100A8/A9 and its counter receptor TLR4/MD2 on platelets in the regulation of inflammation, glycocalyx integrity and vascular permeability during inflammation

P6

Exploring the mechanisms of cytokine storm induction and systemic infection by highly pathogenic influenza viruses

Kidney

P7

The effect of DAMPs and remote ischemic preconditioning on the prevention of acute kidney injury

P8

The role of glutamine in acute kidney injury

Core Project

Z

Immune system variables in healthy subjects and during systemic inflammation

Pilot Projects

Z

Immune system variables in healthy subjects and during systemic inflammation