Bridging Basic Science and Clinical Research
An integral approach
Individual Excellence. Common Success.
The molecular mechanisms of organ damage during systemic inflammation and sepsis are incompletely understood. Importantly, no specific treatment strategy exists to efficiently prevent the development of multi-organ failure during systemic inflammation. The central aim of the Clinical Research Unit CRU342 is the identification and investigation of relevant molecular, immunological and cellular pathways involved in organ dysfunction during systemic inflammation and sepsis, and the identification and investigation of therapeutic treatment strategies.
This will lead to the development of new treatment approaches for patients suffering from systemic inflammatory syndromes and sepsis. The Clinical Research Unit CRU342 comprises projects focusing on different organ systems in the fields of inflammation, cell biology, imaging, microbiology and clinical management of sepsis and organ failure. The CRU342 provides a strong research network combining individual projects investigating different aspects of systemic inflammation and organ dysfunction.
Cooperative Research Network
Immune system dysregulation and endothelial dysfunction are major factors contributing to the deleterious effects of systemic inflammation. We acknowledge this by a comprehensive view on the consequences of this pathological processes on the lung and the kidneys, two of the major organ systems which are most often affected during organ dysfunction following systemic inflammation.
Endothelium
P1
Procalcitonin as a mediator of sepsis-induced endothelial barrier dysfunction
P2
How VE-PTP and Tie-2 regulate endothelial cell junctions in VE-cadherin dependent and independent ways [finished]
Immune System
P3
P4
Characterization of the interaction of bacterial determinants
and host cells during systemic inflammation for sepsis prediction [finished]
Lung
P5
The role of the alarmin S100A8/A9 and its counter receptor TLR4/MD2 on platelets in the regulation of inflammation, glycocalyx integrity and vascular permeability during inflammation
P6
Exploring the mechanisms of cytokine storm induction and systemic infection by highly pathogenic influenza viruses
Kidney
P7
The effect of DAMPs and remote ischemic preconditioning on the prevention of acute kidney injury
P8
The role of glutamine in acute kidney injury
Core Project
Z
Immune system variables in healthy subjects and during systemic inflammation
Pilot Projects
PP1
Effects of hypoalbuminemia on endothelial S1P signaling in sepsis
PP2
Effect of Propofol versus sevoflurane on the renoprotective effects of remote ischemic preconditioning (RIPC) in high-risk patients undergoing cardiac surgery
PP3
Proteomic-based identification and validation of novel candidate mediators for damage and refurbishment of the endothelial glycocalyx in bacterial sepsis and COVID-19
PP4
Improving the prediction of renal recovery from acute kidney injury using artificial intelligence
PP5
Immune reaction after use of cardiopulmonary bypass