Bridging Basic Science and Clinical Research

An integral approach

Individual Excellence. Common Success.

The molecular mechanisms of organ damage during systemic inflammation and sepsis are incompletely understood. Importantly, no specific treatment strategy exists to efficiently prevent the development of multi-organ failure during systemic inflammation. The central aim of the Clinical Research Unit CRU342 is the identification and investigation of relevant molecular, immunological and cellular pathways involved in organ dysfunction during systemic inflammation and sepsis, and the identification and investigation of therapeutic treatment strategies.

This will lead to the development of new treatment approaches for patients suffering from systemic inflammatory syndromes and sepsis. The Clinical Research Unit CRU342 comprises projects focusing on different organ systems in the fields of inflammation, cell biology, imaging, microbiology and clinical management of sepsis and organ failure. The CRU342 provides a strong research network combining individual projects investigating different aspects of systemic inflammation and organ dysfunction.

Cooperative Research Network

Immune system dysregulation and endothelial dysfunction are major factors contributing to the deleterious effects of systemic inflammation. We acknowledge this by a comprehensive view on the consequences of this pathological processes on the lung and the kidneys, two of the major organ systems which are most often affected during organ dysfunction following systemic inflammation.  




The Role of Bacteria-derived Outer-Membrane-Vesicles (OMVs) in the Inducation of Systemic Inflammation and Organ Damage


How VE-PTP and Tie-2 regulate endothelial cell junctions in VE-cadherin dependent and independent ways [finished]

Immune System


Targeting nociceptors to modulate neutrophil mobilization and homing in sepsis


Myeloid differentiation in systemic inflammation


Characterization of the interaction of bacterial determinants
and host cells during systemic inflammation for sepsis prediction [finished]



Effects of the Alarmin S100A8/A9 on the Platelet and Neutrophil Response during Pulmonary Inflammation


Disease-tailored therapeutic strategies against hyperinflammatory viral infections caused by highly pathogenic respiratory viruses


Role of neuropilin-1 on lung macrophages during pulmonary inflammation



Multidimensional profiling of novel mediators and therapeutic targets related to AKI during systemic inflammation


The renin-angiotensin II axis: a novel target for the treatment of acute kidney injury

Core Project


Immune system variables in healthy subjects and during systemic inflammation

Pilot Projects from 2020-2023


Effects of hypoalbuminemia on endothelial S1P signaling in sepsis


Effect of Propofol versus sevoflurane on the renoprotective effects of remote ischemic preconditioning (RIPC) in high-risk patients undergoing cardiac surgery


Proteomic-based identification and validation of novel candidate mediators for damage and refurbishment of the endothelial glycocalyx in bacterial sepsis and COVID-19


Improving the prediction of renal recovery from acute kidney injury using artificial intelligence


Immune reaction after use of cardiopulmonary bypass